PARKINSON_DISEASE

作品数:125被引量:198H指数:7
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相关作者:余舒扬陈滢陈晓春王涛张巧俊更多>>
相关机构:首都医科大学附属北京天坛医院福建医科大学环境与疾病相关基因教育部重点实验室西安交通大学更多>>
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相关基金:国家自然科学基金北京市自然科学基金国家重点基础研究发展计划陕西省自然科学基金更多>>
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Parkinson Disease Patient with Wheezing Manifestations: A Case Report
《Journal of Geriatric Medicine》2021年第1期19-20,共2页Mimi Zhou Siyuan Jing Yue Chen 
The dosing of anti-Parkinson drugs is considered as the optimal control of the symptoms of PD,and increasing the dose of drugs is a common method to treat the aggravate state of PD.However,this is a case of PD elderly...
关键词:Parkinson’s disease Anti-Parkinson drugs Renal dysfunction OVERDOSE WHEEZE 
Secondary Parkinson disease caused by breast cancer during pregnancy: A case report
《World Journal of Clinical Cases》2019年第23期4052-4056,共5页Lei Li 
Chinese Academy of Medical Sciences Initiative for Innovative Medicine,No.CAMS-2017-I2M-1-002;National Sciencetechnology Support Plan Projects,No.2015BAI13B04
BACKGROUND Paraneoplastic neurological syndrome manifesting as secondary Parkinson disease caused by breast cancer is extremely rare.CASE SUMMARY We report a 39-year-old primipara of 31 gestational weeks,who presented...
关键词:SECONDARY PARKINSON disease BREAST NEOPLASMS PREGNANCY Case report 
Tetramethylpyrazine analogue T-006 promotes clearance of alpha-synuclein by enhancing proteasome activity in Parkinson disease models被引量:1
《中国药理学与毒理学杂志》2019年第9期658-659,共2页ZHOU He-feng SHAO Min GUO Bao-jian LI Chu-wen LU Yu-cong YANG Xuan-jun LI Sheng-nan LI Hai-tao ZHU Qi ZHONG Han-bing WANG Yu-qiang ZHANG Zai-jun LU Jia-hong LEE Ming-yuen Simon 
Science and Technology Development Fund(FDCT)of Macao SAR(069/2015/A2;134/2014/A3;062-2017-AIR);Research Committee,University of Macao(MYRG2015-00182-ICMS-QRCM;MYRG2015-00214-ICMSQRCM;MYRG139(Y1-L4)-ICMS12-LMY;and MYRG2016-00129-ICMS-QRCM)
OBJECTIVE To investigate the effects of T-006(tetramethylpyrazine derivative)in promotingα-Synuclein(α-Syn)degradation and evaluated the neuroprotective effects in cellular and animalα-Syn model of Parkinson diseas...
关键词:Α-SYNUCLEIN degradation LMP7 proteasome activity Parkinson disease 
Quantitative autonomic function test in differentiation of multiple system atrophy from idiopathic Parkinson disease被引量:1
《Chinese Medical Journal》2019年第16期1919-1924,共6页Ji-Yun Park Dongseok Yang Hei-Jun Yang Hyun Ah Kim Saeromi Kim Deokhyun Heo Jeong-Ho Park Eek-Sung Lee Tae-Kyeong Lee 
Background:Differential diagnosis of idiopathic Parkinson disease (IPD) and multiple system atrophy-Parkinson type (MSA-P) is challenging since they share clinical features with parkinsonism and autonomic dysfunction....
关键词:PARKINSON disease Multiple system ATROPHY AUTONOMIC DYSFUNCTION Cardiovascular AUTONOMIC indexes 
Virtual reality for Parkinson disease
《中华物理医学与康复杂志》2019年第5期358-358,共1页Maggio MG De Cola MC Latella D 
BACKGROUND AND OBJECTIVE The prevalence of Parkinson's disease ( PD) in industrialized countries is 0.3% in the general population. This study evaluated the effects of virtual reality training ( VRT) on motor and cogn...
关键词:Parkinson's disease(PD) virtual REALITY training(VRT) RECOVERY 
Study on characteristics of transcranial sonography in Parkinson disease with dementia
《China Medical Abstracts(Internal Medicine)》2018年第4期233-234,共2页YUAN Xiaoli 
Objective To investigate the characteristics of Transcranial Sonography(TCS)in Parkinson disease patients with or without dementia.Methods One hundred sixty-three subjects including 58 PDD,64 n-PDD,and 41 controls wer...
关键词:the CHARACTERISTICS PARKINSON TRANSCRANIAL 
Upregulation of TREM2 attenuates neuroinflammation and dopaminergic neurotoxicity in MPTP model mice with Parkinson disease
《中国药理学与毒理学杂志》2018年第9期684-684,共1页REN Man-ru GUO Ying WEI Xin-bing YAN Shao-qi QIN Yue ZHANG Bin LOU Hai-yan 
Shandong Province Science and Technology Program (2016GSF201061).
OBJECTIVE To investigate the role of triggering receptor expressed on myeloid cells-2(TREM2) in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) model mice with Parkinson disease(PD) and explore the underlying s...
关键词:triggering receptor expressed on MYELOID cells-2 PARKINSON disease microglia NEUROINFLAMMATION 
NP-6 Rb Fraction Combined with Levodopa Prevent Parkinson Disease by Protecting Neurovascular Unit
《神经药理学报》2018年第4期105-105,共1页CHI Bin-bin LIAN Xiao-yuan 
Object:Parkinson disease(PD)is the second most common progressive neurodegenerative disorder.The available therapies for PD only treat the symptoms of the disease,without neuroprotective and disease-modifying effects....
关键词:PARKINSON disease GINSENOSIDES LEVODOPA NEUROVASCULAR unit NEUROPROTECTION 
Parkinson Kinetic Graph: Are Motor Fluctuations in Parkinson Disease Related with Disease Duration?被引量:1
《Advances in Parkinson's Disease》2018年第1期1-6,共6页Esther Berghuis Barbera Van Harten Mirjam Van Kesteren-Biegstraaten Wijnand Rutgers Nicolaas Verwey 
Introduction: The Parkinson’s KinetiGraph (PKG) is a digital measurement system for motor fluctuations (FS). The aim of this study is to investigate whether FS, measured by the PKG, are associated with disease durati...
关键词:Late Stage PARKINSON DISEASE LEVODOPA DISEASE Duration Fluctuations DYSKINESIA BRADYKINESIA 
A small-molecule activator of ULK1 that induces cytoprotective autophagy for Parkinson disease treatment被引量:1
《中国药理学与毒理学杂志》2017年第10期981-981,共1页Lan ZHANG Da-hong YAO Guan WANG 
supported by National Natural Science Foundation of China(81602953);China Postdoctoral Special Science Foundation(2017T100706);China Postdoctoral Science Foundation(2016M590893)
OBJECTIVE To discover a small-molecule activator of ULK1 for Parkinson disease treatment and exploreits potential mechanisms.METHODS Candidate ULK1 activator was found by using structure-based design and high-through ...
关键词:AUTOPHAGY Parkinson disease UNC-51-like kinase 1 ULK1 activator ULK complex 
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