PATHOLOGICAL

作品数:446被引量:1256H指数:15
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相关领域:医药卫生更多>>
相关作者:金娟吴晶涛魏栋胡卫星李俊漾更多>>
相关机构:重庆医科大学浙江省人民医院江苏省苏北人民医院华中师范大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Current understanding and prospects for targeting neurogenesis in the treatment of cognitive impairment
《Neural Regeneration Research》2026年第1期141-155,共15页Ye Liu Xibing Ding Shushan Jia Xiyao Gu 
supported by Technological Innovation 2030-Major Projects of“Brain Science and Brain-like Research,”No.2022ZD0206200(to XG);the National Natural Science Foundation of China,No.82371245(to SJ),82102246(to XD),81701092(to XG);the Natural Science Foundation of Shandong Province,No.ZR2020MH129(to SJ);Shanghai Municipal Key Clinical Specialty,No.shslczdzk03601;Shanghai Engineering Research Center of Peri-operative Organ Support and Function Preservation,No.20DZ2254200。
Adult hippocampal neurogenesis is linked to memory formation in the adult brain,with new neurons in the hippocampus exhibiting greater plasticity during their immature stages compared to mature neurons.Abnormal adult ...
关键词:aging Alzheimer's disease cerebrovascular diseases cognitive impairment energy metabolism HIPPOCAMPUS immune mechanisms NEUROGENESIS pathological states TREATMENT 
Shared mechanisms and pathological phenotypes underlying aminoacyl-tRNA synthetase-related neuropathies
《Neural Regeneration Research》2026年第1期312-313,共2页Elena R.Rhymes James N.Sleigh 
funding from the Medical Research Council (MR/S006990/1, MR/Y010949/1);the Rosetrees Trust (M806);the UCL Neurogenetic Therapies Programme funded by The Sigrid Rausing Trust and the UCL Therapeutic Acceleration Support scheme supported by funding from MRC IAA 2021 UCL MR/X502984/1 (to JNS)。
Charcot-Marie-Tooth disease(CMT) is a heterogeneous group of inherited peripheral neuro pathies;it is characterized by muscle weakness and wasting,as well as sensory dysfunction,that typically begins during adolescenc...
关键词:conduction DEGENERATE typically 
Shedding light on the retina to see healthy and pathological aging
《Neural Regeneration Research》2025年第12期3537-3538,共2页Marília Inês Móvio Maria Camila Almeida Sergio T.Ferreira Alexandre Hiroaki Kihara 
With the advances in medicine and technology,life expectancy has increased significantly in recent decades.While this is positive news,it also brings major challenges to public health systems.As people live longer,the...
关键词:DISEASES ALZHEIMER cases 
A dysregulated calcium homeostasis as the earliest pathological sign in stem cell-derived Parkinson's disease neurons?
《Neural Regeneration Research》2024年第7期1421-1422,共2页Nilima Prakash 
Parkinson’s disease(PD) is characterized by the slow and progressive demise of dopamine(DA)-synthesizing neurons in the substantia nigra pars compacta(SNc),a nucleus located in the human ventral midbrain.Neuron death...
关键词:HOMEOSTASIS DOPAMINE DEATH 
Soluble alpha-synuclein post-translational modifications:unexpected regulators of pathological alpha-synuclein amplification
《Neural Regeneration Research》2024年第5期959-960,共2页Simran Kapila Yuhan Sun Chao Peng Shujing Zhang 
The build-up of misfoldedα-synuclein(α-syn)in the central nervous system is the pathological hallmark of a number of neurodegenerative diseases that are known asα-synucleinopathies.These include Parkinson’s diseas...
关键词:PATHOLOGICAL DISEASES 
Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system被引量:4
《Neural Regeneration Research》2024年第4期855-862,共8页Mingyue Jin Shengming Wang Xiaodie Gao Zhenyou Zou Shinji Hirotsune Liyuan Sun 
supported by the Natural Science Foundation of Guangxi Zhuang Autonomous Region,Nos.2022GXNSFAA035622(to MJ),2020GXNSFAA297048(to ZZ);the National Natural Science Foundation of China,No.82060268(to ZZ)。
α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,respectively.Previous works have revealed that intracellular deposition...
关键词:ALPHA-SYNUCLEIN microtubule-associated protein neurodegenerative disease TAU 
Physiological and pathological functions of circular RNAs in the nervous system
《Neural Regeneration Research》2024年第2期342-349,共8页Min Zhou Shi Li Chuan Huang 
supported by the National Natural Science Foundation of China,Nos.32270601 and 32070633(to CH);the Chongqing Talents Plan for Young Talents No.cstc2022ycjh-bgzxm0140(to CH);the Innovation Support Program for Overseas Returned Scholars of Chongqing,China,No.cx2019142(to CH);the Natural Science Foundation of Chongqing of China,No.cstc2021jcyj-bshX0121(to MZ)。
Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and tissues.CircRNAs play crucial roles in physiological and pathological proces...
关键词:Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease 
Pathological and therapeutic effects of extracellular vesicles in neurological and neurodegenerative diseases被引量:3
《Neural Regeneration Research》2024年第1期55-61,共7页Paula lzquierdo-Altarejos Victoria Moreno-Manzano Vicente Felipo 
supported in part by the Ministerio de Ciencia e Innovacion Spain(PID2020-113388RB-I00 to VF and PID2021-124359OB-100 to VMM);Conselleria Educacion Generalitat Valenciana(CIPROM/2021/082 to VF);co-funded with European Regional Development Funds(ERDF)to VF and VMM。
Extracellular vesicles are released by all cell types and contain proteins,microRNAs,mRNAs,and other bioactive molecules.Extracellular vesicles play an important role in intercellular communication and in the modulati...
关键词:extracellular vesicles INFLAMMATION cognitive function mesenchymal stem cells neurodegenerative diseases NEUROINFLAMMATION THERAPY transforming growth factor-β 
A pancreatic player in dementia:pathological role for islet amyloid polypeptide accumulation in the brain
《Neural Regeneration Research》2023年第10期2141-2146,共6页Angelina S.Bortoletto Ronald J.Parchem 
supported by The Mike Hogg Fund;Baylor College of Medicine Medical Scientist Training Program,NICHD R01HD099252(to RJP)and R01HD098131(to RJP);the NHLBI T32 HL092332(to ASB)。
Type 2 diabetes mellitus patients have a markedly higher risk of developing dementia.While multiple factors contribute to this predisposition,one of these involves the increased secretion of amylin,or islet amyloid po...
关键词:Alzheimer’s disease AMYLIN AMYLOID DEMENTIA diabetes human islet amyloid polypeptide islet amyloid polypeptide PROTOFIBRILS type 2 diabetes mellitus vascular dementia 
Myelinosome organelles in pathological retinas: ubiquitous presence and dual role in ocular proteostasis maintenance被引量:1
《Neural Regeneration Research》2023年第5期1009-1016,共8页Marina G.Yefimova 
The timely and efficient elimination of aberrant proteins and damaged organelles, formed in response to various genetic and environmental stressors, is a vital need for all cells of the body. Recent lines of evidence ...
关键词:autophagy Huntington’s disease Müller cells myelinosome-driven secretion myelinosomes ocular pathophysiology PROTEOSTASIS retina retinal pigmented epithelium ubiquitin-proteasome system 
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