DYSREGULATION

作品数：170被引量：528H指数：10
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相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy
《Neural Regeneration Research》2025年第8期2264-2278,共15页You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao 
supported by the National Natural Science Foundation of China,No.82271214(to ZY);the Natural Science Foundation of Hubei Province of China,No.2022CFB109(to ZY)。
Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments.The current therapeutic strategies,primarily based on cholinest...
关键词：Alzheimer’s disease glial cells GLYCOLYSIS neuronal metabolism PATHOGENESIS therapeutic targets 
Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease
《Neural Regeneration Research》2025年第3期808-810,共3页Iqira Saeed Linlin Ma 
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeost...
关键词：HOMEOSTASIS CLINICAL subsequent 
Dysregulation of RNA modification systems in clinical populations with neurocognitive disorders被引量：5
《Neural Regeneration Research》2024年第6期1256-1261,共6页Helen M.Knight Merve DemirbugenÖz Adriana PerezGrovas-Saltijeral 
funded by Notingham University and the Neuroscience Support Group Charity,UK(to HMK);supported by a CONACYT PhD scholarship;MD?was supported by the Postdoctoral Research Fellowship Program of TUBITAK。
The study of modified RNA known as epitranscriptomics has become increasingly relevant in our understanding of disease-modifying mechanisms.Methylation of N6 adenosine(m^(6)A)and C5 cytosine(m^(5)C)bases occur on mRNA...
关键词：5-methylcytosine methylation Alzheimer's disease cognitive diseases epitranscriptomics intellectual disability Lewy body diseases N6 adenosine RNA modification 
Altered O-GlcNAcylation and mitochondrial dysfunction,a molecular link between brain glucose dysregulation and sporadic Alzheimer's disease被引量：5
《Neural Regeneration Research》2023年第4期779-783,共5页Chia-Wei Huang Nicholas C.Rust Hsueh-Fu Wu Gerald W.Hart 
supported by the Georgia Research Alliance and the University of Georgia(to GWH)。
Alzheimer’s disease is a neurodegenerative disease that affected over 6.5 million people in the United States in 2021,with this number expected to double in the next 40 years without any sort of treatment.Due to its ...
关键词：Alzheimer’s disease amyloid beta BRAIN glucose deficiency glucose uptake HYPOMETABOLISM mitochondrial dysfunction neurodegenerative disease neurons O-GlcNAc Tau 
Interplay of SOX transcription factors and microRNAs in the brain under physiological and pathological conditions被引量：2
《Neural Regeneration Research》2022年第11期2325-2334,共10页Milena Stevanovic Danijela Stanisavljevic Ninkovic Marija Mojsin Danijela Drakulic Marija Schwirtlich 
the Ministry of Education,Science and Technological Development of the Republic of Serbia(Agreement number 451-03-9/2021-14/200042,to MiS,DSN,MM,DD and MaS);the Serbian Academy of Sciences and Arts(Grant number F24,to MiS(PI),MM,DD and MaS)。
Precise tuning of gene expression,accomplished by regulato ry networks of transcription factors,epigenetic modifiers,and microRNAs,is crucial for the proper neural development and function of the brain cells.The SOX t...
关键词：dysregulation of miRNA expression glioblastoma GLIOGENESIS glioma stem cells ischemic stroke neural stem cells neural tissue regeneration neurodegenerative diseases NEURODEVELOPMENT NEUROGENESIS SOX/miRNA interplay traumatic brain injury 
SARS-CoV-2-induced autophagy dysregulation may cause neuronal dysfunction in COVID-19
《Neural Regeneration Research》2022年第6期1255-1256,共2页Madepalli K.Lakshmana 
the National Institute of Health(No.1R21AG060299)to MKL.
The devastating outbreak of the ongoing coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has affected not only the lives of almost everyone around the world but al...
关键词：acute RESPIRATORY PROMPT 
Could autophagy dysregulation link neurotropic viruses to Alzheimer’s disease?被引量：6
《Neural Regeneration Research》2019年第9期1503-1506,共4页Maria Anele Romeo Alberto Faggioni Mara Cirone 
supported by Human Herpesvirus-6 Foundation and Istituto Pasteur Italia-Fondazione Cenci Bolognetti(to MC)
Neurotropic herpesviruses have been associated with the onset and progression of Alzheimer’s disease,a common form of dementia that afflicts a large percentage of elderly individuals.Interestingly,among the neurotrop...
关键词：Alzheimer’s disease AUTOPHAGY HHV-6A HHV-6B HSV-1 neurotropic viruses amyloidβ tau protein reactive oxygen species inflammation AD 
Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain?被引量：1
《Neural Regeneration Research》2019年第7期1148-1151,共4页Zhefan Stephen Chen Ho Yin Edwin Chan 
supported by the General Research Fund(14100714)of the Hong Kong Research Grants Council(to HYEC);The Chinese University of Hong Kong Vice-Chancellor’s One-Off Discretionary Fund(VCF2014011)(to HYEC);The Chinese University of Hong Kong One-of Funding for Joint Lab/Research Collaboration(3132980)(to HYEC);The Chinese University of Hong Kong Faculty of Science Strategic Development Fund(FACULTY-P17173)(to HYEC);The Chinese University of Hong Kong Gerald Choa Neuroscience Centre(7105306)(to HYEC);donations from Chow Tai Fook Charity Foundation(6903898)(to HYEC);Hong Kong Spinocerebellar Ataxia Association(6903291)(to HYEC);supported by the Postdoctoral Fellowship in Clinical Neurosciences of The Chinese University of Hong Kong,China
Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration...
关键词：Alzheimer’s disease amyotrophic lateral SCLEROSIS neurodegeneration PROTEIN aggregates recruitment PROTEIN degradation SUBCELLULAR localization TRANSCRIPTIONAL regulation YIN Yang 1 
Depression following a traumatic brain injury:uncovering cytokine dysregulation as a pathogenic mechanism被引量：6
《Neural Regeneration Research》2018年第10期1693-1704,共12页Colleen N.Bodnar Josh M.Morganti Adam D.Bachstetter 
supported in part by a Kentucky Spinal and Head Injury Trust trainee fellowship;supported by National Institutes of Health under award numbers R00 AG044445(to ADB);P30 GM110787(to ADB)
A substantial number of individuals have long-lasting adverse effects from a traumatic brain injury（TBI）. Depression is one of these long-term complications that influences many aspects of life. Depression can limit...
关键词：CONCUSSION major-depressive disorder chronic traumatic encephalopathy inflammation tumor necrosis factor α interleukin 1 microglia astrocytes synaptic physiology N-methyl-D-aspartic acid 
What can computational modeling offer for studying the Ca^(2+) dysregulation in Alzheimer's disease:current research and future directions被引量：2
《Neural Regeneration Research》2018年第7期1156-1158,共3页Jingyi Liang Don Kulasiri 
Ca^2＋ dysregulation is an early event observed in Alzheimer＇s disease（AD） patients preceding the presence of its clinical symptoms.Dysregulation of neuronalCa^2＋ will cause synaptic loss and neuronal death,eventu...
关键词：Alzheimer＇s disease amyloid-beta Ca^2＋ hypothesis Ca^2＋ dysregulation computational modeling computational neuroscience 
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