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GLOBIN: 作品数：52被引量：68H指数：4; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李承军黄有文王荣新邱长春陈朝更多>>; 相关机构：南京大学教育部华侨大学北京协和医学院更多>>; 相关期刊：《Chinese Medical Sciences Journal》《Progress in Natural Science:Materials International》《Chinese Journal of Chemistry》《生物工程学报》更多>>; 相关基金：国家自然科学基金更多>>

Reduction of BCL11A in hematopoietic stem cells through gene editing:new strategy to ameliorate the severe b-globin disorders sickle cell disease: 《Science Bulletin》2019年第21期1562-1564,共3页Weiqi Hong Mengyuan Huang Yuquan Wei Xiawei Wei; Site-specific gene editing is of great importance in precise medicine. Two conventional genome editing methods, Zine finger nucleases (ZFNs) and transcription activator-like effector nucleases(TALENs), are based on pr...; 关键词：CRISPR/Cas9 TALENs ZFNs

Interactions between HMG proteins (HMG1/2 and HMG14/17) and human ε-globin gene promoter (ε-promoter): 《Chinese Science Bulletin》2002年第18期1543-1546,共4页Chunhui Hou Jian Huang Shubing Zhang Ruolan Qian; This work was supported by the National Natural Science Foundation of China (Grant No. 39893320);the Foundation of Chinese Academy of Sciences (Grant No. KJ 951 -A 1 -603 (2)).; High mobility group (HMG) proteins are abundant non-histone proteins in the nuclei of eukaryocytes. It has been shown that HMG proteins may play important roles in the structure and function of chromatin. In the prese...; 关键词：HMG PROTEINS HUMAN ε-globin gene PROMOTER in vitro NUCLEOSOME reconstitution HMG PROTEINS purification EMSA.

A novel erythroid differentiation related gene EDRF2 inhibited α-globin gene expression in K562 cells: 《Chinese Science Bulletin》2002年第5期398-402,共5页WANG Duncheng, YANG Xiaoming & SHEN BeifenInstitute of Basic Medical Sciences, Institute of Radiation Medicine Sciences, Academy of Military Sciences, Beijing 100850, China; In previous studies, we found that EDRF2 was an erythroid differentiation related factor, whose expression was markedly upregulated during erythroid differentiation. It suggested that this factor played a role in eryt...; 关键词：GLOBIN gene ERYTHROID specific TRANSCRIPTION factors LEUCINE ZIPPER RACE EMSA.

Effects of point mutation C→T at - 64 of human δ globin gene promoter on DNA binding proteins: 《Chinese Science Bulletin》1999年第17期1576-1581,共6页Haiping Kou Songsen Chen Weidong Chen Jingqiu Zhang Xu Di Zhiquan Liang; By electrophoretic mobility shift assay (EMSA), the effect of point mutation C→T at - 64 of human δ-globin gene on its binding proteins has been studied. Two segments of 36 bp from - 83- - 48 bp of the 6 globin gene...; 关键词：δ GLOBIN gene PROMOTER BINDING PROTEINS electrophoretic mobility SHIFT assay.

Developmental stage-specific factors in the mouse haematopoietic tissues binding to the 5'-flanking as-acting elements of humanε-globin gene被引量：1: 《Chinese Science Bulletin》1995年第9期778-783,共6页严志江陈雅娣钱若兰; Project supported by grants from Shanghai Joint Laboratory of Life Sciences, the Chinese Academy of Sciences, and the National Natural Science Foundation of China.; The human ε-globin gene is expressed in a tissue-specific and developmental stage-specific manner. During the earliest stage of gestation, this gene is expressed in the yolksac, but is silenced completely at the 6th-...; 关键词：HUMAN ε-globin gene cis-acting element trans-acting factor.

A NOVEL β-THALASSEMIA MUTATION——DELETION OF 4bp (-AAAC)DOWNSTREAM FROM THE CAP SITE: 《Chinese Science Bulletin》1991年第21期1846-1848,共3页徐永华吴涤梵彭素芬张美兰周霞娣任兆瑞黄淑帧曾溢滔; This work was supported by NIH Research Grant HL-29623; β-Thalassemia is a common monogenic blood disorder, caused by the mutations in the β-globin locus. This letter reports a new type of β thalassemia mutation that we encountered during the investigation of the molecu...; 关键词：GLOBIN letter locus MUTATION A NOVEL DNA Polymerase BamHI DELETION PLASMID

CHARACTERIZATION OF β-THALASSEMIA MUTATIONS IN CHINESE USING OLIGONUCLEOTIDE HYBRIDIZATION WITH AMPLIFIED DNA: 《Chinese Science Bulletin》1990年第3期261-262,共2页黄淑帧周霞娣朱皓任兆瑞曾溢滔; β-Thalassemia is a relatively common monogenic disorder in China. Up to the present, over 60 different mutations have been found to cause β-thalassemia in the world; and each ethnic group or population carries its o...; 关键词：alleles mutant populations migration ETHNIC pathogenesis DNA prevention carries GLOBIN

PRENATAL DIAGNOSIS OF THALASSEMIAS BY USING POLYMERASE CHAIN REACTION (PCR): 《Chinese Science Bulletin》1989年第15期1317-1318,共2页张基增蔡仕萍黄道华王仲祥简悦威; DNA analysis has become the method of choice for diagnosis of many genetic disorders. In 1978 Kan and Dozy described the first useful restriction fragment length polymorphism (RFLP) in the β globin gene cluster which...; 关键词：linkage length ANEMIA GLOBIN DELETION DNA SPANNING mutant PARENTS elusion

ISOLATION AND CHARACTERIZATION OF OPIOID BINDING SITES FROM HUMAN PLACENTAE: 《Chinese Science Bulletin》1987年第10期704-707,共4页李志毅周德和范曼芳池志强; It has been demonstrated that there are multiple opioid receptors in the brain of animals and men. The relationship between various subtype receptors and their physiological functions and the true biochemical basis ab...; 关键词：OPIOID biochemical PLACENTA physiological contained SUBTYPE ANALGESIC separated suspension GLOBIN

POLYMORPHISM AND HAPLOTYPE IN β-GLOBIN GENE CLUSTER IN CHINESE: 《Chinese Science Bulletin》1987年第2期144-,共1页曾溢滔黄淑帧; The polymorphism of 8 restriction endonuclease sites in Ghinese β-globin gene cluster and the haplotype were determined in ten normal subjects and fifteen patients with β-thalassemia major and their parents. The fre...; 关键词：PARENTS POLYMORPHIC ENDONUCLEASE HAPLOTYPE GLOBIN carrying analysed DNA assoc deter

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