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Widespread arginine phosphorylation in human cells——a novel protein PTM revealed by mass spectrometry被引量：2
《Science China Chemistry》2020年第3期341-346,共6页Songsen Fu Chuan Fu Quan Zhou Rongcan Lin Han Ouyang Minning Wang Ying Sun Yan Liu Yufen Zhao 
supported by National Natural Science Fundation of China(21977085,21502159 to C.Fu,91856126,21778042 to YF Zhao).
Arginine phosphorylation(p Arg)is recently discovered as a ubiquitous protein N-phosphorylation in bacteria.However,its prevalence and roles in mammalian cells remain largely unknown due to the lack of established wor...
关键词：protein ARGININE PHOSPHORYLATION N-phosphorylation PROTEOMICS mass SPECTROMETRY human cells 
Raman micro-spectrometry as a technique for investigating heterogeneous reactions on individual atmospheric particles被引量：5
《Science China Chemistry》2011年第1期154-160,共7页ZHAO DeFeng,ZHU Tong,CHEN Qi,LIU YingJun & ZHANG ZeFeng State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China 
financially supported by the National Natural Science Foundation of China (20637020, 40490265 & 20077001);National Basic Research Program of China (2002CB410802);special fund of State Key Joint Laboratory of Environment Simulation and Pollution Control
Investigating the heterogeneous reaction on individual atmospheric particles is important because it approximates actual atmospheric conditions and can aid in reducing artifacts in elucidating real mechanisms and proc...
关键词：Raman microspectrometry individual atmospheric particle heterogeneous reaction 
Identification of secondary organic aerosols based on aerosol mass spectrometry被引量：2
《Science China Chemistry》2010年第12期2593-2599,共7页HUANG XiaoFeng 1,ZHAO QianBiao 1,2,HE LingYan 1,HU Min 2,BIAN QiJing 3,XUE Lian 1 & ZHANG YuanHang 2 1 Key Laboratory for Urban Habitat Environmental Science and Technology School of Environment and Energy,Peking University Shenzhen Graduate School,Shenzhen 518055,China 2 State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China 3 Division of Environment,Hong Kong University of Science & Technology,Hong Kong,China 
supported by the National Natural Science Foundation of China(40805049 & 20777001);Science and Technology Plan Project of Shenzhen Municipality(CXB200903090046A);Open Fund of State Key Joint Laboratory of Environmental Simulation and Pollution Control,Peking University
Secondary organic aerosol (SOA) is one of the major components of aerosols in the atmosphere and has not been well understood so far.Due to the complex chemical composition of organic aerosols,the identification of SO...
关键词：SECONDARY organic AEROSOL AEROSOL mass SPECTROMETRY POSITIVE matrix FACTORIZATION (PMF) 
EGFR/cell membrane chromatography-online-high performance liquid chromatography/mass spectrometry method for screening EGFR antagonists from Radix Angelicae Pubescentis被引量：5
《Science China Chemistry》2010年第11期2357-2362,共6页SiCen Wang Meng Sun YanMin Zhang Jie Zhang LangChong He 
supported by the National Natural Science Foundation of China (30730110);Program for New Century Excellent Talents in University (NCET-08-0437)
The intracellular kinase domains of the epidermal growth factor receptor(EGFR) in some tumor cells are significant targets for drug discovery.We have developed a new EGFR cell membrane chromatography(EGFR/CMC)-online-...
关键词：EGFR cell membrane chromatography high performance liquid chromatography/mass SPECTROMETRY ANTI-EGFR ANTAGONISTS RADIX Angelicae Pubescentis 
Simultaneous determination of five anti-epilepsy drugs in human plasma using liquid chromatography-mass spectrometry被引量：1
《Science China Chemistry》2010年第11期2373-2378,共6页STEFANIE WeiBig 
supported by the National Science & Technology Major Project (2009ZX09301-14);the National Natural Science Foundation of China (90817103,20775055 & 30973672);the Startup Funding for ZC’s Luojia Chair Professorship of Wuhan University (306276216 & 306271159);the Fundamental Research Funds for the Central Universities
A new liquid chromatography-mass spectrometry method for the determination of carbamazepine,clonazepam,alprazolam,estazolam and phenytoin in human plasma has been developed by using diazepam as an internal standard.Ch...
关键词：liquid chromatography-mass SPECTROMETRY anti-epilepsy DRUGS plasma CONCENTRATION 
Recent advances in proteolysis and peptide/protein separation by chromatographic strategies被引量：2
《Science China Chemistry》2010年第4期685-694,共10页ZHANG XiangMin1, LIU BaoHong1, ZHANG LiHua2, ZOU HanFa2, CAO Jing1, GAO MingXia1, TANG Jia1, LIU Yun1, YANG PengYuan1 & ZHANG YuKui2 1Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China 2Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China 
support from the Major State Basie Research Development Program (Grant No. 2007CB914100);the National Natural Science Foundation of China (Grant Nos. 20875016 & 20735005);Shanghai Projects (Grant Nos. 08DZ2293601 & B109)
This review gives a broad glance on the progress of recent advances on proteolysis and peptide/protein separation by chroma-tographic strategies in the past ten years, covering the main research in these areas especia...
关键词：PROTEOLYSIS ENZYMATIC DIGESTION CHROMATOGRAPHIC separation PEPTIDE enrichment mass SPECTROMETRY 
Recent developments of nanoparticle-based enrichment methods for mass spectrometric analysis in proteomics被引量：1
《Science China Chemistry》2010年第4期695-703,共9页ZHANG LiJuan, LU HaoJie & YANG PengYuan Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China 
support from the Major State Basie Research Development Program (Grant No. 2007CB914100);the National Natural Science Foundation of China (Grant Nos. 20875016 & 20735005);the Ph.D. Programs Foundation of the Ministry of Education of China (Grant No. 200802460011);Shanghai Projects (Grant Nos. 08DZ2293601, Eastern Scholar, Shu Guang and B109)
In proteome research, rapid and effective separation strategies are essential for successful protein identification due to the broad dynamic range of proteins in biological samples. Some important proteins are often e...
关键词：ENRICHMENT nanoparticles mass SPECTROMETRY PROTEOMICS PHOSPHORYLATION GLYCOSYLATION 
Mass spectrometry analysis of melanoma related O-glycans in sera
《Science China Chemistry》2010年第4期807-811,共5页BAI Chen1,4, WU Gang1 & ZHAO Liang2,3 1Department of Life Science, Fudan University, Shanghai 200433, China 2Department of Chemistry, Fudan University, Shanghai 200433, China 3Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China 4Department of Food Science, Shanghai Business School, Shanghai 200235, China 
support from the Innovation Program of Shanghai Municipal Education Commission (Grant No. 10YZ212);the National Natural Science Foundation of China (Grant No. 30900254)
Glycomics comparison was carried out by screening melanoma serum biomarkers between C57 mice with and without B16 implanted. O-glycans were released from 10 μL sera by β-elimination, purified by Graphitized Carbon C...
关键词：mass SPECTROMETRY GLYCOMICS MELANOMA biomarkers 
Separation of small molecular peptides with the same amino acid composition but different sequences by high performance liquid chromatography-electrospray ionization-mass spectrometry
《Science China Chemistry》2009年第12期2264-2268,共5页LIU LiHong CHEN ZiLin 
Supported by the National Natural Science Foundation of China (Grant Nos. 20775055 & 90817103) ;the Start-up Funding for ZC’s Luojia Chair Professor-ship of Wuhan University (Grant No. 306276216)
Peptidomics has emerged as a new discipline in recent years. Mass spectrometry (MS) is the most universal and efficient tool for structure identification of proteins and peptides. However,there is a limitation for the...
关键词：REVERSED-PHASE CHROMATOGRAPHY mass SPECTROMETRY PEPTIDES AMINO acid 
Cu(Ⅰ) and Cu (Ⅱ) helical complexes formed with oligobipyridine ligand
《Science China Chemistry》1999年第5期501-510,共10页舒谋海 付有君 孙为银 唐雯霞 张文剑 段春迎 
Project supported by the National Natural Science Foundation of China (Grant No. 29601003).
A new asymmetric oligobipyridine ligand, l-( 5'-methyl-2, 2'-bipyridin-5-yl )-2-( 6'-methyl-2, 2'-bipyridin-6-yl)ethane (L) , in which the bipyridine units are bridged by CH2CH2 at 5 ,6'-position has been synthesized....
关键词：HELIX copper complex SUPRAMOLECULE self-assembly crystal structure ELECTROSPRAY mass spectrometry. 
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