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HOMEOSTASIS: 作品数：942被引量：3744H指数：25; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：祁红金正均陈红专朱戈李洋更多>>; 相关机构：军事医学科学院中国科学院上海第二医科大学首都医科大学附属北京口腔医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>

Decoding the intracellular trafficking rule for circular RNAs: 《Science China(Life Sciences)》2025年第2期590-592,共3页Jiao Li Xiaojuan Yang Yong Peng; supported by the National Natural Science Foundation of China(82273168);the 1.3.5 Project for Disciplines of Excellence,West China Hospital of Sichuan University(ZYGD23027)。; Circular RNAs(circRNAs)are endogenous single-stranded RNAs with a covalently closed loop generated from'backsplicing'of precursor mRNA(pre-mRNA)in the nucleus.Mounting evidence emphasizes their significance in cellula...; 关键词：ENDOGENOUS HOMEOSTASIS DISEASES

DTD1 modulates synaptic efficacy by maintaining D-serine and D-aspartate homeostasis: 《Science China(Life Sciences)》2025年第2期467-483,共17页Xiao Liu Chaojuan Yang Zhuoran Lin Jianing Li Bin Yin Xuepei Lei Wei Han Boqin Qiang Pengcheng Shu Chen Zhang Xiaozhong Peng; supported by the National Science and Technology Innovation 2030 Grants of China(2021ZD0200902 to Peng,X.);the National Key Research and Development Program of China(2017YFA0105201 to Zhang,C.);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(CIFMS;2021-1-I2M-019 to Shu,P.and 2021-1-I2M-024 to Peng,X.);the National Natural Science Foundation of China(31670789 to Peng,X.,32370883 to Shu,P.,81925011 to Zhang,C.,82001145 to Yang,C.);the State Key Laboratory Special Fund 2060204。; D-serine and D-aspartate are involved in N-methyl-D-aspartate receptor(NMDAR)-related physiological and pathological processes.Daminoacyl-t RNA deacylase 1(DTD1)may biochemically contribute to D-serine or D-aspartate ...; 关键词：D-aminoacyl-tRNA deacylase 1 D-SERINE D-ASPARTATE synaptic transmission neuronal morphology spatial learning and memory

Immune states:integrated views of immunity by combining traditional Chinese medicine and modern medicine被引量：2: 《Science China(Life Sciences)》2024年第10期2271-2273,共3页Anlong Xu Yuxing Zhi; Human immune system is an extraordinarily complex physiological system composed of multiple anatomical systems,diverse tissues and molecules from macroscopic to microscopic level.Numerous cells and molecules collectiv...; 关键词：IMMUNITY HOMEOSTASIS IMMUNE

LncRNA CCRR maintains Ca^(2+)homeostasis against myocardial infarction through the FTO-SERCA2a pathway被引量：1: 《Science China(Life Sciences)》2024年第8期1601-1619,共19页Hua Yang Lina Xuan Shengjie Wang Huishan Luo Xiaomeng Duan Jianjun Guo Shijia Cui Jieru Xin Junwei Hao Xiufang Li Jun Chen Feihan Sun Xiaolin Hu Siyun Li Ying Zhang Lei Jiao Baofeng Yang Lihua Sun; supported by the National Natural Science Foundation of China(81970202,81903609,U21A20339);the Natural Science Foundation of Heilongjiang Province,China(LH2022H002);the Outstanding Young Talent Research Fund of College of Pharmacy,Harbin Medical University(2019-JQ-02);2021(the second batch)Research Funds for affiliated research institutes in Heilongjiang Province(CZKYF2021-2-C013).; Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier investigation.This study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in ...; 关键词：CCRR calcium homeostasis FTO myocardial infarction SERCA2A

GCGR:novel potential therapeutic target for chronic kidney disease: 《Science China(Life Sciences)》2024年第7期1542-1544,共3页Yan Hu Hao Huang Rong Xiang; supported by the National Natural Science Foundation of China(82003102,82300787,82170598);Hunan Provincial Key Field R&D Plan Project(2022SK2034);Natural Science Foundation of Hunan Province(2022JJ30058,2021JJ40992);the Youth Science Foundation of Xiangya Hospital(2021Q11)。; The kidney,a central regulator of systemic homeostasis essential for human health,plays a vital role in various metabolic pathways,including fatty acid metabolism,gluconeogenesis,glycolysis,and mitochondrial metabolis...; 关键词：KIDNEY METABOLISM HOMEOSTASIS

Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders: 《Science China(Life Sciences)》2024年第6期1170-1182,共13页Jiaming Liu Liangkui Li Dijin Xu Yuqi Li Tao Chen Yeyang Liu Yuqian Bao Yan Wang Longyan Yang Peng Li Li Xu; supported by the National Key Research and Development Program of China(2018YFA0506901,2019YFA0801701,2022YFA0806502);the National Natural Science Foundation of China(92254308,92157107);the Lingang Laboratory(LG-QS-202204-06)。; Metabolically healthy obesity refers to obese individuals who do not develop metabolic disorders.These people store fat in subcutaneous adipose tissue(SAT)rather than in visceral adipose tissue(VAT).However,the molecu...; 关键词：Rab18 subcutaneous adipose tissue(SAT) metabolically healthy obesity(MHO) LIPOTOXICITY ER stress ectopic lipid storage LD-ER contact

Precision regulation of plant aromatic amino acid homeostasis: 《Science China(Life Sciences)》2024年第6期1316-1317,共2页Jie Luo; The aromatic amino acids(AAAs)phenylalanine(Phe),tyrosine(Tyr),and tryptophan(Trp)are not only building blocks of proteins,but also precursors of numerous primary and specialized metabolites(Schenck and Maeda,2018).Fo...; 关键词：AROMATIC instance COUMARIN

Paracrine function amplifies pro-tumor electrochemical signal within neuron-glioma synapses: 《Science China(Life Sciences)》2024年第6期1318-1320,共3页Yan Hu Peishan Hu Xiaozhong Peng; supported by the National Natural Science Foundation of China(82003102)。; Neuronal activity plays a pivotal role in various physiological processes,including tissue development,homeostasis,and adaptability.Advances in recent years have improved our understanding of neuronal activity in brai...; 关键词：GLIOMA HOMEOSTASIS FUNCTION

Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis被引量：6: 《Science China(Life Sciences)》2024年第5期865-878,共14页Wei Jia Yitao Li Kenneth C.P.Cheung Xiaojiao Zheng; supported by the National Natural Science Foundation of China(82122012,82270917);Shanghai Research Center for Endocrine and Metabolic Diseases(2022ZZ01002)。; Bile acids(BAs)play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis.Through the enterohepatic circulation,BAs are synthesized,metabolized,and reab...; 关键词：bile acid whole body METABOLISM IMMUNITY

Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging: 《Science China(Life Sciences)》2024年第4期745-764,共20页Shujie Chen Liujing Huang Bingdong Liu Huimin Duan Ze Li Yifan Liu Hu Li Xiang Fu Jingchao Lin Yinlan Xu Li Liu Dan Wan Yulong Yin Liwei Xie; supported by the Guangdong Basic and Applied Basic Research Foundation(2020B1515020046);“GDAS”Project of Science and Technology Development(2021GDASYL20210102003,2018GDASCX-0102);the National Natural Science Foundation of China(82072436,32130099);Open Program of Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics(GPKLMMD-OP202102);Outstanding Youth Fund of Hunan Natural Science Foundation(2021JJ20045);the Outstanding Youth Fund of Hunan Natural Science Foundation(2021JJ20045);Youth Innovation Promotion Association of Chinese Academy of Sciences(2022370)。; The gut microbiota plays a pivotal role in systemic metabolic processes and in particular functions,such as developing and preserving the skeletal muscle system.However,the interplay between gut microbiota/metabolites...; 关键词：gut microbiota AGING satellite cells BUTYRATE Slc16a1(Mct1)

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