supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033;FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research;by CiberNed Intramural Collaborative Projects(ref.PI2020/09);by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that...
Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain processes.While dopamine is primarily associated with pleasure,reward,and motivation,its effect...
The present paper addresses two issues pertaining to the use of virtual reality(VR).One issue pertains to the equipment utilized.VR technology can be classified into two main categories:Immersive and non-immersive.The...
supported by an under-40 grant from the Italian Association for Alzheimer’s Research [AIRALZH AGYR2021];the Strategic University Projects–Young Researcher Independence grant [YRG2021] from the Università Campus Bio-Medico di Roma (Rome, Italy)(to LLB);Italian Ministry of Health [Research Grant:GR-2019-12370446];the American Alzheimer’s Association [AARG-22-922961](to PK)。
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histologi...
funded in part by Aligning Science Across Parkinson’s(ASAP-020572);NIH grants(R01NS121371 and R21NS135545);Department of Defense Congressionally Directed Medical Research Programs(W81XWH-21-1-0943);Parkinson’s Foundation(PF-IMP-1045313).
The locus coeruleus norepinephrine(LC-NE)system plays an important role in regulating brain function,and its neuronal loss has been well-documented in Parkinson’s disease(PD).The LC-NE neurodegeneration is believed t...
BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower limbs.RLS typically affects the legs.However,it can also affect several other body regions,such as th...
supported by funding from Parkinson Canada;funded by a scholarship from Parkinson Canada;a scholarship from Fonds d’Enseignement et de Recherche (FER) (Faculty of Pharmacy, Université Laval)
There is a need to develop interventions to slow or reverse the degeneration of dopamine neurons in Parkinson’s disease after diagnosis.Given that preclinical and clinical studies suggest benefits of dietary n-3 poly...
partially supported by the National Institutes of Health(NIH)grants DA056213(to Alexander K.Zinsmaier),DA053388(to Eric J.Nestler),DA023206(to Yan Dong),DA060868(to Yan Dong),and DA040620(to Eric J.Nestler and Yan Dong)。
Understanding the cellular mechanisms of drug addiction remains a key task in current brain research.While neuron-based mechanisms have been extensively explored over the past three decades,recent evidence indicates a...
supported by National Key R&D Program of China(Grant No.2022YFC2401800);National Natural Science Foundation of China(Grant No.32301116);Sichuan Science and Technology Program(Grant No.2023NSFSC0996)
The objective of regenerative wound healing dressings is to accelerate skin tissue regeneration and restore normal physiological function at wound sites.Achieving this goal requires biomaterials capable of repairing d...
supported by grants from STI 2030-Major Projects(2021ZD0203203,2021ZD02044400);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32000000);the National Natural Science Foundation of China(31871066,31922028,and 31900721);the Shanghai Municipal Science and Technology Major Project(2018 SHZDZX05).
Dear Editor,Instinctual male mating actions serve the fundamental purpose of bringing the two gametes together in sexually reproducing species[1,2].Upon encountering a conspecific female,a male mouse investigates the ...