HAMSTERS

作品数：39被引量：112H指数：7
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ApoL1 risk allele accelerates high-fat diet-induced atherosclerosis in LDLR-/-hamsters
《Genes & Diseases》2025年第2期136-139,共4页Yitong Xu Wenxi Zhang Jiabao Guo Jinxuan Chen Guolin Miao Lianxin Zhang Yufei Han Jingxuan Chen Ying Zhao Xunde Xian 
supported by the National Natural Science Foundation of China (No.82070460,82270479,HY2021-1 to X.Xian);the Fundamental Research Funds for the Central Universities (China) (to X.Xian);the Beijing Natural Science Foundation (No.7242084 to X.Xian).
Apolipoprotein L1(ApoL1),coded by ApoL1 gene that is only expressed in humans,gorillas,and green monkeys,is largely synthesized by the liver and incorporated into highdensity lipoprotein(HDL),playing beneficial,roles ...
关键词：ALLELE INFLAMMATION ATHEROSCLEROSIS 
Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters被引量：1
《Virologica Sinica》2024年第6期909-916,共8页Shaohong Chen Xinghai Zhang Yanfeng Yao Shengdong Wang Kangyin Li Baoyue Zhang Tianxi Ye Li Chen Yan Wu Entao Li Bichao Xu Pei Zhang Xia Chuai Yong Ran Rui Gong Huajun Zhang Sandra Chiu 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0490000).
Nipah virus(NiV)is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia.NiV leads to severe respiratory disease and encephalitis in humans and animals,with a mortality rate of up to 75...
关键词：Nipah virus(NiV) Ferritin nanoparticles Vaccine candidate 
Acoustic complexity of pup isolation calls in Mongolian hamsters: 3-frequency phenomena and chaos
《Current Zoology》2024年第5期559-574,共16页Marina V.Rutovskaya Ilya A.Volodin Natalia Y.Feoktistova Alexey V.Surov Anna V.Gureeva Elena V.Volodina 
Studying pup isolation calls of wild rodents provides background for developing new early-life animal models for biomedical research and drug testing.This study discovered a highly complex acoustic phenotype of pup is...
关键词：audible and ultrasonic vocalization CRICETINAE nonlinear phenomena pup isolation calls RODENTS wild animal models 
Increased pathogenicity and aerosol transmission for one SARS-CoV-2 B.1.617.2 Delta variant over the wild-type strain in hamsters被引量：2
《Virologica Sinica》2022年第6期796-803,共8页Xinghai Zhang Shaohong Chen Zengguo Cao Yanfeng Yao Junping Yu Junhui Zhou Ge Gao Ping He Zhuo Dong Jie Zhong Jing Luo Hongping Wei Huajun Zhang 
supported by China Natural Science Foundation (82150201)
During the two-year pandemic of coronavirus disease 2019(COVID-19), its causative agent, severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has been evolving. SARS-CoV-2 Delta, a variant of concern, has beco...
关键词：SARS-CoV-2 B.1.617.2 Delta variant Syrian hamsters PATHOGENICITY Transmission 
Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates被引量：2
《Cell Research》2022年第10期949-952,共4页Yi Wu Yanqiong Shen Namei Wu Xinghai Zhang Shaohong Chen Chang Yang Junhui Zhou Yan Wu Da Chen Li Wang Chao Wang Huajun Zhang Ninuo Xia Sandra Chiu Yucai Wang 
supported by the National Key R&D Program of China(2020YFA0710700);the National Natural Science Foundation of China(52025036,51961145109);the Fundamental Research Fund for the Central Universities(WK9100000014,WK2480000006,and WK9110000061);the project of collaborative innovation for colleges of Anhui province(GXXT-2021-070).
Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected more than 400 million people globally,resulting in millions of deaths.1 As the virus evolves,a new variant,designated as“Omicron”by...
关键词：PFIZER IMMUNITY LIKELY 
A highly immunogenic live-attenuated vaccine candidate prevents SARS-CoV-2 infection and transmission in hamsters被引量：1
《The Innovation》2022年第2期126-135,共10页Xiao-Feng Li Zhen Cui Hang Fan Qi Chen Lei Cao Hong-Ying Qiu Na-Na Zhang Yan-Peng Xu Rong-Rong Zhang Chao Zhou Qing Ye Yong-Qiang Deng Yan Guo Si Qin Kaiyue Fan Lei Wang Zijing Jia Yujun Cui Xiangxi Wang Cheng-Feng Qin 
This work was supported by the National Key Research and Development Program of China(No.2020YFC0840900,2018YFA0900801 and 2020YFA0707500);the Strategic Priority Research Program(XDB29010000,XDB37030000),CAS(YSBR-010);the Emergency Key Programof Guangzhou Laboratory(No.EKPG21-09);the Beijing Municipal Science and Technology Project(No.Z201100001020004,Z201100005420017);the National Natural Science Foundation of China(No.82171820,No.12034006,and No.81921005);C.-F.Q.was supported by the National Science Fund for Distinguished Young Scholars(81925025);the Innovative Research Group(81621005)from the NSFC;the Innovation Fund forMedical Sciences(2019-I2 M-5-049)from the Chinese Academy of Medical Sciences.
The highly pathogenic and readily transmissible SARS-CoV-2 has caused a global coronavirus pandemic,urgently requiring effective countermeasures against its rapid expansion.All available vaccine platforms are being us...
关键词：VACCINE ATTENUATED INFECTION 
Lipid nanoparticle-encapsulated mRNA antibody provides longterm protection against SARS-CoV-2 in mice and hamsters被引量：8
《Cell Research》2022年第4期375-382,共8页Yong-Qiang Deng Na-Na Zhang Yi-Fei Zhang Xia Zhong Sue Xu Hong-Ying Qiu Tie-Cheng Wang Hui Zhao Chao Zhou Shu-Long Zu Qi Chen Tian-Shu Cao Qing Ye Hang Chi Xiang-Hui Duan Dan-Dan Lin Xiao-Jing Zhang Liang-Zhi Xie Yu-Wei Gao Bo Ying Cheng-Feng Qin 
supported by the National Natural Science Foundation of China(NSFC)(82151222,82041044 and 81801583);the National Key R&D Project of China(2021YFC2302400,2020YFC0842200);C.-F.Q.was supported by the National Science Fund for Distinguished Young Scholars(81925025);the Innovative Research Group(81621005)from the NSFC;the Innovation Fund for Medical Sciences(2019-I2M-5-049)from the Chinese Academy of Medical Sciences.
Monoclonal antibodies represent important weapons in our arsenal to against the CO VID-19 pandemic.However,this potential is severely limited by the time-consuming process of developing effective antibodies and the re...
关键词：LIPID prevention consuming 
Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice被引量：5
《Acta Pharmaceutica Sinica B》2022年第3期1322-1338,共17页Fengfeng Li Man Jiang Minghui Ma Xuyang Chen Yidan Zhang Yixin Zhang Yuanyuan Yu Yunfeng Cui Jiahui Chen Hui Zhao Zhijie Sun Deli Dong 
supported by the National Natural Science Foundation of China(Nos.81773725 and 91739102)。
Lipid metabolism disorders contribute to hyperlipidemia and hepatic steatosis.It is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic steatosis.Nitazoxanide is an FDA-approved oral antiprot...
关键词：NITAZOXANIDE Tizoxanide HYPERLIPIDEMIA Hepatic steatosis AMPK Autophagy SQSTM1/P62 Mitochondrial uncoupling 
Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters被引量：1
《Signal Transduction and Targeted Therapy》2022年第3期632-634,共3页Ya-Nan Zhang Zhe-Rui Zhang Hong-Qing Zhang Na Li Qiu-Yan Zhang Xiao-Dan Li Cheng-Lin Deng Fei Deng Shuo Shen Bing Zhu Bo Zhang 
We thank the National Key Research and Development Program of China(2018YFA0507201)for grant support.We thank the National Virus Resource center for making Omicron available.
Dear Editor,The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continues to disrupt global public health since its first report in December 2019,resulting in more than 380 billi...
关键词：ACUTE PATHOGENESIS RESPIRATORY 
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
《四川生理科学杂志》2021年第1期118-118,共1页Alina Baum 
An urgent global quest for effective therapies to prevent and treat coronavirus disease 2019(COVID-19)is ongoing.We previously described REGN-COV2,a cocktail of two potent neutralizing antibodies(REGN10987 and REGN109...
关键词：REG ANTIBODIES ACUTE 
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