METABOLOMIC

作品数：175被引量：496H指数：12
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Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study
《World Journal of Gastroenterology》2024年第11期1572-1587,共16页Shi-Ju Chen Da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-Ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai 
Supported by the Innovation Platform for Academicians of Hainan Province,No.YSPTZX202313;Hainan Province Clinical Medical Center,No.2021818;Hainan Provincial Health Industry Research Project,No.22A200078;Hainan Provincial Postgraduate Innovation Research Project,No.Qhyb2022-133;Hainan Medical University Graduate Student Innovative Research Project,No.HYYB2022A18;Nanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine,No.2020-3HIM.
BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transpl...
关键词：Crohn’s disease Clinical trials Fecal microbiota transplant METAGENOME Metatranscriptome METABOLOME 
Molecular advances in pancreatic cancer:A genomic,proteomic and metabolomic approach
《World Journal of Gastroenterology》2021年第31期5171-5180,共10页Srujan Rajesh Michael J Cox Franscois Runau 
Pancreatic ductal adenocarcinoma(PDAC)represents a challenging pathology with very poor outcomes and is increasing in incidence within the general population.The majority of patients are diagnosed incidentally with in...
关键词：Pancreatic ductal adenocarcinoma Pancreatic adenocarcinoma GENOMIC PROTEOMIC METABOLOMIC 
Mitochondrial metabolomic profiling for elucidating the alleviating potential of Polygonatum kingianum against high-fat diet-induced nonalcoholic fatty liver disease被引量：8
《World Journal of Gastroenterology》2019年第43期6404-6415,共12页Xing-Xin Yang Jia-Di Wei Jian-Kang Mu Xin Liu Feng-Jiao Li Yan-Qin Li Wen Gu Jing-Ping Li Jie Yu 
the National Natural Science Foundation of China,No.81660596;the National Natural Science Foundation of China,No.81760733;the Science and Technology Project of Yunnan China,No.2017FF117-013;the Science and Technology Project of Yunnan China,No.2016FD050;the Application and Basis Research Project of Yunnan China,No.201801CH00227
BACKGROUND Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of nonalcoholic fatty liver disease(NAFLD).Polygonatum kin...
关键词：Metabolomics MITOCHONDRIA Multivariate statistical analysis Non-alcoholic FATTY liver POLYGONATUM kingianum Ultra-high performance liquid chromatography/mass SPECTROMETRY 
Integrated metabolomic profiling for analysis of antilipidemic effects of Polygonatum kingianum extract on dyslipidemia in rats被引量：11
《World Journal of Gastroenterology》2018年第48期5505-5524,共20页Xing-Xin Yang Jia-Di Wei Jian-Kang Mu Xin Liu Jin-Cai Dong Lin-Xi Zeng Wen Gu Jing-Ping Li Jie Yu 
Supported by the National Natural Science Foundation of China,No.81660596 and No.81760733;the Application and Basis Research Project of Yunnan,China,No.2016FD050 and No.2017FF117-013;the Fund for Young and Middle-aged Academic and Technological Leaders of Yunnan,No.2015HB053
AIM To identify the effects and mechanism of action of Polygonatum kingianum(P. kingianum) on dyslipidemia in rats using an integrated untargeted metabolomic method.METHODS A rat model of dyslipidemia was induced with...
关键词：DYSLIPIDEMIA LIPID regulation Metabolomics Multivariate statistical ANALYSIS POLYGONATUM kingianum Ultra-high performance liquid chromatography/mass SPECTROMETRY 
Metabolomic alterations and chromosomal instability status in gastric cancer被引量：8
《World Journal of Gastroenterology》2018年第33期3760-3769,共10页Cheng-Kun Tsai Ta-Sen Yeh Ren-Chin Wu Ying-Chieh Lai Meng-Han Chiang Kuan-Ying Lu Cheng-Yu Hung Hung-Yao Ho Mei-Ling Cheng Gigin Lin 
Supported by the Ministry of Science and Technology Taiwan grant,No.MOST 106-2314-B-182A-019-MY3;the Chang Gung Foundation,No.CMRPG3E1321-2,No.IRB201601916B0,and No.IRB103-7448B
AIM To explore the correlation of metabolomics profiles ofgastric cancer(GC) with its chromosomal instability(CIN) status.METHODS Nineteen GC patients were classified as CIN and nonCIN type by The Cancer Genome Atlas ...
关键词：GASTRIC cancer Metabolomics ONCOGENE COPY-NUMBER CHROMOSOMAL instability Liquid chromatography-mass SPECTROMETRY 
Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome被引量：8
《World Journal of Gastroenterology》2018年第8期894-904,共11页Lei-Min Yu Ke-Jia Zhao Shuang-Shuang Wang Xi Wang Bin Lu 
Supported by the National Natural Science Foundation of China,No.81470814 and No.81400594;Zhejiang Provincial Natural Science Foundation of China,No.LQ14H160014
AIM To study the role of microbial metabolites in the modulation of biochemical and physiological processes in irritable bowel syndrome(IBS).METHODS In the current study, using a metabolomic approach, we analyzed the ...
关键词：IRRITABLE BOWEL syndrome METABOLITE Gas chromatography/mass spectrometry CLOSTRIDIUM butyricum 
Metabolomic profiling for identification of metabolites and relevant pathways for taurine in hepatic stellate cells被引量：4
《World Journal of Gastroenterology》2017年第31期5713-5721,共9页Xin Deng Xing-Qiu Liang Fei-Guo Lu Xiao-Fang Zhao Lei Fu Jian Liang 
Supported by National Natural Science Foundation of China,No.81360595 and No.81360532;Guangxi Natural Science Foundation Program,No.2014GXNSFDA118027;Bagui Scholars Foundation Program of Guangxi;Special-term Experts Foundation Program of Guangxi
AIM To develop a reliable and simple method to identify important biological metabolites and relevant pathways for taurine in hepatic stellate cells(HSCs), in order to provide more data for taurine therapy.METHODS All...
关键词：Natural taurine Hepatic stellate cells Pathway High performance liquid chromatographytime electrospray ionization/quadrupole-time of flight mass spectrometry Metabolomics 
Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study被引量：11
《World Journal of Gastroenterology》2017年第21期3890-3899,共10页Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman 
Supported by Alberta Innovates-Bio Solutions;a graduate studentship from Alberta Innovates-Health Solutions(to Keshteli AH)
AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were ...
关键词：Ulcerative colitis RELAPSE Metabolomics DIET Fecal calprotectin 
Pancreatic cancer early detection:Expanding higher-risk group with clinical and metabolomics parameters被引量：4
《World Journal of Gastroenterology》2015年第6期1707-1717,共11页Shiro Urayama 
Pancreatic ductal adenocarcinoma(PDAC)is the fourth and fifth leading cause of cancer death for each gender in developed countries.With lack of effective treatment and screening scheme available for the general popula...
关键词：PANCREATIC cancer ENDOSCOPIC ultrasound Metabolomi 
Metabolomic studies of human gastric cancer:Review被引量：22
《World Journal of Gastroenterology》2014年第25期8092-8101,共10页Naresh Doni Jayavelu Nadav S Bar 
Supported by Research Council of Norway,NO.70174300
Metabolomics is a field of study in systems biology that involves the identification and quantification of metabolites present in a biological system. Analyzing metabolic differences between unperturbed and perturbed ...
关键词：Metabolomics Gastric cancer CHEMOSENSITIVITY METASTASIS Biomarkers Nuclear magnetic resonance spectroscopy Liquid/gas chromatography and mass spectrometry 
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