supported by the Zhejiang Provincial Natural Science Foundation of China(LR23H270001 and LQ22H270006);National Natural Science Foundation of China(82274280 and 82305005).
In individuals afflicted with hemophilia,characterized by a deficiency of coagulation factor VIII(FVIII),the occurrence of spontaneous recurrent intra-articular hemorrhage precipitates the emergence of hemophilic arth...
Background: Hindfoot fusion, is a fusion of the talonavicular, talocalcaneal, and calcaneocuboid joints and is commonly performed for patients complaining of pain, chronic instability and gross deformity as a result o...
CAMS Innovation Fund for Medical Sciences(CIFMS,No.2022-I2M-C&T-B-031);National High Level Hospital Clinical Research Funding(No.2022-PUMCH-A-124)
Background:Total knee arthroplasty(TKA)can reduce severe joint pain and improve functional disability in hemophilia.However,the long-term outcomes have rarely been reported in China.Therefore,this study aimed to evalu...
BACKGROUND Hemophilia A is a rare inherited bleeding disorder caused by mutations in the factor Ⅷ gene. This clotting factor plays an intrinsic role in the blood coagulation pathway. Patients with hemophilia may deve...
BACKGROUND Hyperuricemia is a prerequisite for the development of gout.Elevated serum uric acid(UA)levels result from either overproduction or decreased excretion.A positive correlation between serum UA levels,cirrhos...
BACKGROUND Ochronosis,also known as alkaptonuria,is a rare autosomal recessive selfmetabolic disease arising from deficiency of homogentisate 1,2 dioxygenase enzyme.It affects several organs and muscoskeletal structur...
BACKGROUND Multiple myeloma(MM)can be accompanied by amyloidosis,which occurs in a small number of patients and is characterized by deposition of light chains in the joints,leading to multiple myeloma-associated amylo...
Supported by Talent Training Project of Guangdong Provincial Bureau of Traditional Chinese Medicine,No.0103030908;Guangdong Provincial Hospital of Traditional Chinese Medicine and the School of Biomedicine,Chinese University of Hong Kong School of Medicine,Basic Clinical Collaborative Innovation Project,No.YN2018HK04。
BACKGROUND Ochronotic arthropathy(OcA)is a rare disease,which is caused by the accumulation of homogentisic acid in the joint.Patients with OcA have obvious joint pain and the disease progresses rapidly,eventually res...
Osteoarthritis(OA)is the most prevalent joint disease causing major disability and medical expenditures.Synovitis is a central feature of OA and is primarily driven by macrophages.Synovial macrophages not only drive i...
This work was supported by the grants from the National Natural Science Foundation of China(No.81271543);the Medical Science and Technology Research Project of Henan Province(No.2018020470).
Background:Certain hemophilia patients are unable to cooperate with or afford magnetic resonance imaging(MRI)examinations.The purpose of our study was to explore the value of multislice spiral computed tomography(MSCT...