SPHINGOSINE

作品数：80被引量：236H指数：8
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相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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Roles of sphingosine 1-phosphate on tumorigenesis被引量：5
《World Journal of Biological Chemistry》2011年第2期25-34,共10页Hsinyu Lee 
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid with a variety of biological activities.It is generated from the conversion of ceramide to sphingosine by ceramidase and the subsequent conversion of sphingosi...
关键词：SPHINGOSINE 1-phosphate SPHINGOSINE KINASE CERAMIDE ANGIOGENESIS Autophagy TUMORIGENESIS 
To stay or to leave: Stem cells and progenitor cells navigating the S1P gradient被引量：3
《World Journal of Biological Chemistry》2011年第1期1-13,共13页Andrew Hsu Jen-Fu Lee Daniel E Cramer Menq-Jer Lee 
Supported by NIH HL071071 (Lee MJ)
Most hematopoietic stem progenitor cells (HSPCs) reside in bone marrow (BM), but a small amount of HSPCs have been found to circulate between BM and tissues through blood and lymph. Several lines of evidence suggest t...
关键词：Hematopoietic STEM PROGENITOR cells Tissue specific stem/progenitor cells Mesenchymal STEM CELL STEM CELL homing STEM CELL egress Sphingosine-1-phosphate Sphingosine-1-phosphate GRADIENT Sphingosine-1-phosphate receptors 
Role of sphingosine kinase localization in sphingolipid signaling
《World Journal of Biological Chemistry》2010年第12期362-368,共7页Binks W Wattenberg 
Supported by The James Graham Brown Cancer Center and NIH, No. CA111987
The sphingosine kinases, SK1 and SK2, produce the potent signaling lipid sphingosine-1-phosphate (S1P). These enzymes have garnered increasing interest for their roles in tumorigenesis, inflammation, vascular diseases...
关键词：SPHINGOLIPID LIPID signaling CERAMIDE Sphingosine-1-phosphate SPHINGOSINE 
Sphingosine-1-phosphate signaling in vasculogenesis and angiogenesis被引量：6
《World Journal of Biological Chemistry》2010年第10期291-297,共7页Kelley M Argraves Brent A Wilkerson W Scott Argraves 
Supported by Grants from the United States Public Health Service/National Institutes of Health, No. HL080404, HL094883 (Argraves KM) and HL061873, HL095067 (Argraves WS);NIH Training Grant to Improve Cardiovascular Therapies HL007260 (Wilkerson BA);American Heart Association 10PRE3910006 (Wilkerson BA)
Blood vessels either form de novo through the process of vasculogenesis or through angiogenesis that involves the sprouting and proliferation of endothelial cells in pre-existing blood vessels. A complex interactive n...
关键词：Sphingosine-1-phosphate VASCULOGENESIS ANGIOGENESIS G-protein-coupled receptors ENDOTHELIUM 
Roles of sphingosine-1-phosphate signaling in angiogenesis被引量：5
《World Journal of Biological Chemistry》2010年第10期298-306,共9页Yoh Takuwa Yasuo Okamoto Noriko Takuwa Kazuaki Yoshioka 
Supported by Grants from the Ministry of Education, Science, Sports and Culture of Japan and the Japan Society for the Promotion of Science;the Practical Application Research program of Japan Science and Technology Agency Innovation plaza Ishi-kawa
Sphingosine-1-phosphate (S1P) is a blood-borne lipid mediator with pleiotropic biological activities. S1P acts via the specific cell surface G-protein-coupled receptors, S1P1-5. S1P1 and S1P2 were originally identifie...
关键词：Sphingosine-1-phosphate ANGIOGENESIS Angiogenic therapy Rac Akt Vascular MATURATION Endothelial CELLS Bone-marrow-derived CELLS 
Regulation of cancer cell migration and invasion by sphingosine-1-phosphate被引量：4
《World Journal of Biological Chemistry》2010年第10期307-312,共6页James R Van Brocklyn 
Supported by R21 CA124685 from the National Cancer Institute;R01 NS41517 from the National Institute of Neurological Disorders and Stroke
Sphingosine-1-phosphate (S1P) is a bioactive sphingo-lipid that has been implicated in regulation of a number of cancer cell malignant behaviors, including cell proliferation, survival, chemotherapeutic resistance and...
关键词：SPHINGOLIPIDS Cancer INVASION METASTASIS 
Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis被引量：3
《World Journal of Biological Chemistry》2010年第11期321-326,共6页Alirio J Melendez Bernard P Leung 
The importance of sphingosine kinase(SphK)and sphingosine-1-phosphate(S1P)in inflammation has been extensively demonstrated.As an intracellular second messenger,S1P plays an important role in calcium signaling and mob...
关键词：CYTOKINES Inflammation RHEUMATOID ARTHRITIS SPHINGOSINE KINASE Sphingosine-1-phosphate 
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