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Functions of nuclear factor Y in nervous system development,function and health: 《Neural Regeneration Research》2025年第10期2887-2894,共8页Pedro Moreira Roger Pocock; supported by National Health and Medical Research Council GNT1105374,GNT1137645,GNT2000766 and veski Innovation Fellowship(VIF23)to RP.; Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 y...; 关键词：axon guidance CCAAT boxes neuronal degeneration neuronal differentiation neuronal regeneration nuclear factor Y complex transcription factor transcriptional regulation

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology: 《Neural Regeneration Research》2025年第9期2655-2666,共12页Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang; supported by the National Key R&D Program of China,No.2021YFA0805200(to SY);the National Natural Science Foundation of China,No.31970954(to SY);two grants from the Department of Science and Technology of Guangdong Province,Nos.2021ZT09Y007,2020B121201006(both to XJL)。; Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto r.The mutant androgen r...; 关键词：androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model NEURODEGENERATION neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression: 《Neural Regeneration Research》2025年第7期2068-2083,共16页Jing Yao Yuan Li Xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song; supported by a grant from Key Laboratory of Alzheimer's Disease of Zhejiang Province,Institute of Aging,Wenzhou Medical University,No.ZJAD-2021002(to ZW)。; Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in...; 关键词：5′end trimming Alzheimer's disease AMYLOID-BETA amyloid-β-dependent transcription FUBP3 INFLAMMASOME inflammation neuron NLRP3 tau transcription factor

Age-related driving mechanisms of retinal diseases and neuroprotection by transcription factor EB-targeted therapy: 《Neural Regeneration Research》2025年第2期366-377,共12页Samuel Abokyi Dennis Yan-yin Tse; supported by the Start-up Fund for new faculty from the Hong Kong Polytechnic University(PolyU)(A0043215)(to SA);the General Research Fund and Research Impact Fund from the Hong Kong Research Grants Council(15106018,R5032-18)(to DYT);the Research Center for SHARP Vision in PolyU(P0045843)(to SA);the InnoHK scheme from the Hong Kong Special Administrative Region Government(to DYT).; Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecu...; 关键词：age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma NEUROMODULATION PHAGOCYTOSIS photoreceptor outer segment degradation retinal aging transcription factor EB

Bexarotene improves motor function after spinal cord injury in mice被引量：3: 《Neural Regeneration Research》2023年第12期2733-2742,共10页Xingyu Wang Zhihao Shen Haojie Zhang Hao-Jie Zhang Feida Li Letian Yu Hua Chen Kailiang Zhou Hui Xu Sunren Sheng; grants from Zhejiang Provincial Medicine and Health Technology Project,No.2021KY214(to SS);Zhejiang Provincial Science and Technology Project of Traditional Chinese Medicine,No.2021ZB183(to HX)。; Spinal cord injury is a challenge in orthopedics because it causes irreversible damage to the central nervous system.Therefore,early treatment to prevent lesion expansion is crucial for the management of patients with...; 关键词：3-methyladenine AMP-activated protein kinase autophagy BEXAROTENE MITOPHAGY oxidative stress PYROPTOSIS reactive oxygen species spinal cord injury transcription factor E3

DI-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis被引量：12: 《Neural Regeneration Research》2023年第11期2424-2428,共5页Shuai Li Jingyuan Zhao Yan Xi Jiaqi Ren Yanna Zhu Yan Lu Deshi Dong; DI-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.However,the precise underlying mechanism requires further investigation.In this study,we investigated the molecular mechanism of DI-3-n-bu...; 关键词：blood-brain barrier Dl-3-n-butylphthalide hypoxia inducible factor 1α MITOCHONDRIA NEUROPROTECTION oxidative stress reactive oxygen species stroke transcription factor UBIQUITINATION

Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases被引量：2: 《Neural Regeneration Research》2023年第11期2370-2376,共7页Wenlong Xue Jie Zhang Yang Li; STI2030-Major Projects,No.2022ZD0213000;the National Natural Science Foundation of China,Nos.92057103 and 31872820;Shanghai Basic Research Program,No.18ZR1 404000;State Key Laboratory of Drug Research,No.SIMM2004KF-09 (all to YL)。; Millions of people are suffering from Alzheimer’s disease globally,but there is still no effective treatment for this neurodegenerative disease.Thus,novel therapeutic approaches for Alzheimer’s disease are needed,wh...; 关键词：Alzheimer’s disease degradation lysosome biogenesis LYsosome-Enhancing Compounds neurodegenerative diseases post-translational modifications protein aggregates transcription factor EB

Transcriptional regulatory network during axonal regeneration of dorsal root ganglion neurons:laser-capture microdissection and deep sequencing被引量：1: 《Neural Regeneration Research》2023年第9期2056-2066,共11页Li-Li Zhao Tao Zhang Wei-Xiao Huang Ting-Ting Guo Xiao-Song Gu; supported by the National Natural Science Foundation of China,Nos. 31730031 and 32130060;the National Major Project of Research and Development,No. 2017YFA0104700;the Natural Science Foundation of Jiangsu Province,No. BK20202013 (all to XSG)。; The key regulators and regeneration-associated genes involved in axonal regeneration of neurons after injury have not been clarified.In high-throughput sequencing,various factors influence the final sequencing results...; 关键词：Arid5a ATF3 Crem dorsal root ganglion Fosl1 KLF6 laser-capture microdissection NEURON smart-seq2 gene expression profile transcription factor

Chx10+V2a interneurons in spinal motor regulation and spinal cord injury被引量：3: 《Neural Regeneration Research》2023年第5期933-939,共7页Wen-Yuan Li Ling-Xiao Deng Feng-Guo Zhai Xiao-Yu Wang Zhi-Gang Li Ying Wang; supported by the National Natural Science Foundation of China,No. 81870977 (to YW);the Natural Science Foundation of Heilongjiang Province of China,No. JQ2021H004 (to YW);PhD research foundation of Mudanjiang Medicine College,No. 2021-MYBSKY-039 (to WYL);Fundamental Research Funds for Heilongjiang Provincial Universities,No. 2021-KYYWF-0469 (to WYL)。; Chx10-expressing V2 a(Chx10+V2 a) spinal interneurons play a large role in the excitatory drive of motoneurons. Chemogenetic ablation studies have demonstrated the essential nature of Chx10+V2 a interneurons in the re...; 关键词：AXONS central nervous system central pattern generator Chx10 differentiation INTERNEURONS locomotion motor neurons PROPRIOSPINAL spinal cord injuries therapy transcription factor transplantation V2a neuron

Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury被引量：6: 《Neural Regeneration Research》2023年第5期1046-1051,共6页Xiao-Jian Xu Qian-Qian Ge Meng-Shi Yang Yuan Zhuang Bin Zhang Jin-Qian Dong Fei Niu Hao Li Bai-Yun Liu; supported by the National Natural Science Foundation of China,No. 81771327 (to BYL);Construction of Central Nervous System Injury Basic Science and Clinical Translational Research Platform;Budget of Beijing Municipal Health Commission 2020, No. PXM2020_026280_000002 (BYL)。; After brain injury, infiltration and abnormal activation of neutrophils damages brain tissue and worsens inflammation, but the mediators that connect activated neutrophils with neuroinflammation have not yet been full...; 关键词：immune infiltration innate immunity INTERLEUKIN-17A neurodegenerative disease NEUROINFLAMMATION NEUTROPHILS secondary brain injury transcription factor transcriptome traumatic brain injury

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