UTIC

作品数：424被引量：1663H指数：20
导出分析报告
相关领域：医药卫生更多>>
相关作者：朱子军顾春湘赵飞赵以模李文更多>>
相关机构：重庆医科大学泗洪县人民医院山东省寄生虫病防治研究所上海中医药大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金广东省自然科学基金上海市自然科学基金国家重点基础研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
选择条件：
  • 期刊=Signal Transduction and Targeted Therapyx
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
New insights into protein-protein interaction modulators in drug discovery and therapeutic advance
《Signal Transduction and Targeted Therapy》2025年第1期148-179,共32页Hossam Nada Yongseok Choi Sungdo Kim Kwon Su Jeong Nicholas A.Meanwell Kyeong Lee 
supported by Dongguk Univ.Research fund of 2023(S-2023-G0001-00098)as well as the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)[No.2018R1A5A2023127]and[No.2023R1A2C3004599];supported by the BK21 FOUR program,which was funded by the Ministry of Education of Korea through NRF.Lastly,this work was supported by the Korea University grant K2419861.
Protein-protein interactions(PPIs)are fundamental to cellular signaling and transduction which marks them as attractive therapeutic drug development targets.What were once considered to be undruggable targets have bec...
关键词：INSIGHT approval gained 
Iron homeostasis and ferroptosis in human diseases:mechanisms and therapeutic prospects被引量：1
《Signal Transduction and Targeted Therapy》2024年第11期5015-5078,共64页Qin Ru Yusheng Li Lin Chen Yuxiang Wu Junxia Min Fudi Wang 
supported in part by the National Natural Science Foundation of China(31970689 to J.M.,32330047 and 31930057 to F.W.,82071970 to Y.W.and 82072506 to Y.L.);the Science Fund for Distinguished Young Scholars of Hubei Province(2023AFA109 to Y.W.);Hubei Provincial Natural Science Foundation of China(2024AFB971 to Q.R.).
Iron,an essential mineral in the body,is involved in numerous physiological processes,making the maintenance of iron homeostasis crucial for overall health.Both iron overload and deficiency can cause various disorders...
关键词：DISEASES HOMEOSTASIS THERAPEUTIC 
Integrate and conquer:pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities
《Signal Transduction and Targeted Therapy》2024年第11期4776-4778,共3页Debomita Chakraborty Rossana Romero Krishnaraj Rajalingam 
supported from a DKH grant(DKH 70113042);the CRC 1292(TP05)to K.R.K.R.
In a recent article published in Cell by Savage et al.,the authors developed a computational workflow for integrating multi-omics data from readily available public online databases to provide novel insights into the ...
关键词：CANCER therapeutic 
Pre-metastatic niche: formation, characteristics and therapeutic implication
《Signal Transduction and Targeted Therapy》2024年第10期4512-4542,共31页Yuhang Wang Jiachi Jia Fuqi Wang Yingshuai Fang Yabing Yang Quanbo Zhou Weitang Yuan Xiaoming Gu Junhong Hu Shuaixi Yang 
Henan Medical Science and Technology Research Plan(No.LHG120230294,to S.Y.);The China Postdoctoral Science Foundation(No.2023M743201,to S.Y.);National funded postdoctoral researcher program(No.GZB20230671,to S.Y.);Provincial and Ministry Co-constructed Key Projects of Henan Medical Science and Technology(No.SBGJ202102121,to J.H.).
Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes in cancer patients. Before the development of organ-specific metastasis, the formation of a pre-metastatic niche is pivotal ...
关键词：METASTATIC metastasis THERAPEUTIC 
Tertiary lymphoid structures in diseases:immune mechanisms and therapeutic advances
《Signal Transduction and Targeted Therapy》2024年第9期3942-3984,共43页Lianyu Zhao Song Jin Shengyao Wang Zhe Zhang Xuan Wang Zhanwei Chen Xiaohui Wang Shengyun Huang Dongsheng Zhang Haiwei Wu 
supported by Natural Science Foundation of Shandong Province,China(Grant no.ZR2021MH353);Health Science and Technology Team Building Project of Shandong Province.
Tertiary lymphoid structures(TLSs)are defined as lymphoid aggregates formed in non-hematopoietic organs under pathological conditions.Similar to secondary lymphoid organs(SLOs),the formation of TLSs relies on the inte...
关键词：LYMPHOID THERAPEUTIC DISEASES 
Bacterial persisters: molecular mechanisms and therapeutic development
《Signal Transduction and Targeted Therapy》2024年第8期3305-3336,共32页Hongxia Niu Jiaying Gu Ying Zhang 
We acknowledge the support by Zhejiang Provincial Natural Science Foundation of China(LY24H290004);National Natural Science Foundation of China Youth Foundation(81701969);Natural Science Youth Exploration Program(2022JKZKTS03);Open fund for the State Key Laboratory of Pathogenic Biology of Animal Diseases(SKLVEB2021KFKT002)for HXN;National Center for Infectious Disease startup fund(B2022011-1);Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2021R01012);Jinan Microecological Biomedicine Shandong Laboratory project(UNL-2022050B)for YZ.
Persisters refer to genetically drug susceptible quiescent(non-growing or slow growing)bacteria that survive in stress environments such as antibiotic exposure,acidic and starvation conditions.These cells can regrow a...
关键词：MECHANISMS TREATMENT persist 
Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease:insights and therapeutic implications
《Signal Transduction and Targeted Therapy》2024年第5期1781-1783,共3页So Jung Kim Jeongeun Hyun 
This study was supported by the National Research Foundation of Korea(grant number 2021R1C1C1003904 to J.H.)。
The recent article published in Signal Transduction and Targeted Therapy sheds light on the significance of N6-methyladenosine(m6A)methyltransferase-like protein METTL14 in mitigating the progression of metabolic dysf...
关键词：liver HOMEOSTASIS al. 
Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2
《Signal Transduction and Targeted Therapy》2023年第5期2384-2391,共8页Zhijian Xu Danrong Shi Jian-Bao Han Yun Ling Xiangrui Jiang Xiangyun Lu Chuan Li Likun Gong Guangbo Ge Yani Zhang Yi Zang Tian-Zhang Song Xiao-Li Feng Ren-Rong Tian Jia Ji Miaojin Zhu Nanping Wu Chunhui Wu Zhen Wang Yechun Xu Cheng Peng Min Zheng Junling Yang Feifei Du Junliang Wu Peipei Wang Jingshan Shen Jianliang Zhang Yong-Tang Zheng Hangping Yao Weiliang Zhu 
supported by the Natural Science Foundation of Shanghai (21ZR1475600);Science and Technology Commission of Shanghai Municipality (20431900100);Shanghai Science and Technology Committee (19430750100);National Key R&D Program of China (2016YFA0502301 and 2021YFC2301204);Drug development for the newly emerging viral infectious diseases (SIMM010107);Fundamental Research Funds for the Central Universities (2022ZFJH003);Zhejiang Provincial Key Research&Development Program of China (2021C03043 and No.2021C03039).
Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2.Here we report that nelfinavir,an FDA approved drug for the treatment of HIV infection,is ef...
关键词：DRUGS INFECTED treatment 
Metabolic landscape in cardiac aging:insights into molecular biology and therapeutic implications被引量：8
《Signal Transduction and Targeted Therapy》2023年第4期1610-1629,共20页Saiyang Xie Si-Chi Xu Wei Deng Qizhu Tang 
the National Key R&D Program of China(2018YFC1311300);the National Natural Science Foundation of China(No:82170245,81860080,and 82070204);The Regional Innovation and Development Joint Fund of National Natural Science Foundation of China(No.U22A20269).
Cardiac aging is evident by a reduction in function which subsequently contributes to heart failure.The metabolic microenvironment has been identified as a hallmark of malignancy,but recent studies have shed light on ...
关键词：CARDIAC DEGENERATION INVOLVEMENT 
Multi-omics characterization and therapeutic liability of ferroptosis in melanoma被引量：1
《Signal Transduction and Targeted Therapy》2022年第9期3194-3197,共4页Yi He Yu Dong Yong Chen Guanxiong Zhang Hailun Zhang Guang Lei Yanhua Du Xiang Chen Youqiong Ye Hong Liu 
This study was supported by the National Key Research and Development Program of China(2019YFE0120800,2019YFA0111600);the Natural Science Foundation of China for outstanding Young Scholars(82022060);the National Natural Science Foundation of China(81874242,31800979,82073145);the Natural Science Foundation of Hunan Province for outstanding Young Scholars(2019J130040);the National Natural Science Foundation of China(62102455);China Postdoctoral Science Foundation(2020M682587).
Dear Editor,Ferroptosis,an iron-dependent form of programmed cell deathdriven by excessive lipid peroxidation,1has emerged as,apromising andeffective strategy fortrigering cancer celldeath.2,3Insufficient understandin...
关键词：therapeutic MELANOMA PEROXIDATION 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部