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Alzheimer's disease:insights into pathology,molecular mechanisms,and therapy
《Protein & Cell》2025年第2期83-120,共38页Qiuyang Zheng Xin Wang 
supported by the National Key R&D Program of China(2021ZD0202402 and 2021YFA1101401 to X.W.);the National Natural Science Foundation of China(82325018 and U21A20358 to X.W.,82271451 to Q.Z.);the Natural Science Foundation of Fujian Province of China(2021J02004 to X.W.);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120081 to X.W.);the Fundamental Research Funds for the Chinese Central Universities(20720230070 to X.W.and Q.Z.,20720220052 to Q.Z.)。
Alzheimer's disease(AD),the leading cause of dementia,is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain.This condition casts a significant shadow on global health due to ...
关键词：Alzheimer's disease PATHOPHYSIOLOGY risk factors biomarkers prevention 
Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy
《Nano Research》2025年第1期520-544,共25页Genping Fu Yuting Weng Yunfan Li Carl Ho Yiyu Fu Wenxuan Wang Songbin Fu Wenjing Sun Jie Lin Xiaoyu Fan Binbin Jia Mengdi Cai Linlin Li 
supported by the Open Project of the Key Laboratory of Genetic Resources Protection and Disease Prevention and Control of the Ministry of Education of China(No.LPHGRDC2020-002);the Major Marshal List Project of Harbin Medical University(No.HMUMIF-21007);the National Natural Science Foundation of China(No.22305051);the member of Youth Innovation Promotion Association Foundation of CAS,China(No.2023310).
Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration approach.This review firstly...
关键词：nanoparticles drug delivery gastric cancer GLIOMA GLIOBLASTOMA 
Acquired RD3 loss regulates immune surveillance in high-risk and therapy defying progressive neuroblastoma
《Cancer Communications》2024年第12期1427-1430,共4页Poorvi Subramanian Sreenidhi Mohanvelu Dinesh Babu Somasundaram Sheeja Aravindan Natarajan Aravindan 
funded by Department of Defense(DoD CA-210339);Oklahoma Center for the Advancement of Science and Technology(OCAST-HR19-045);the National Institutes of Health(P20GM103639);supported by the National Cancer Institute Cancer Center Support Grant(P30CA225520);a grant from the Oklahoma Tobacco Settlement Endowment Trust(R23-03)both awarded to the OU Health Stephenson Cancer Center.
Neuroblastoma(NB)is the most common extra cranial solid tumor in children and comprises one tenth of all childhood cancer deaths.More than half of infants presented with NB,a designated“cold tumor”with low immune ce...
关键词：NEUROBLASTOMA IMMUNE tumor 
Neoadjuvant sintilimab and apatinib combined with perioperative FLOT chemotherapy for locally advanced gastric cancer:A prospective,single-arm,phase Ⅱ study
《Chinese Medical Journal》2024年第21期2615-2617,共3页Huinian Zhou Bo Long Zeyuan Yu Junmin Zhu Hanteng Yang Changjiang Luo Wenjuan Zhang Chi Dong Xiaoying Guan Long Li Gengyuan Zhang Hongtai Cao Shigong Chen Linyan Zhou Qichen He Shiying Gan Xiangyan Jiang Qianlin Gu Keshen Wang Wengui Shi Long Qin Zuoyi Jiao 
supported by Jiangsu Hengrui Medicine Co.,Ltd.&Innovent Biologics(Suzhou)Co.,Ltd,the Fundamental Research Funds for the Central Universities of Lanzhou University(Nos.lzujbky-2022-ey04 and lzujbky-2023-eyt04);the Science and Technology Program of Gansu Province,China(Nos.21JR1RA144 and 22JR5RA961);the Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital,China(Nos.CY2020-MS10 and CY2023-QN-A02).
For patients with locally advanced gastric cancer(LAGC),the effectiveness of perioperative chemotherapy can be significantly improved by adding programmed cell death protein 1(PD-1)inhibitors during the neoadjuvant ph...
关键词：CHEMOTHERAPY DEATH cancer 
Type 2 diabetes mellitus in adults:pathogenesis,prevention and therapy被引量：3
《Signal Transduction and Targeted Therapy》2024年第11期4791-4815,共25页Xi Lu Qingxing Xie Xiaohui Pan Ruining Zhang Xinyi Zhang Ge Peng Yuwei Zhang Sumin Shen Nanwei Tong 
supported by the National Nature Science Foundation of China(82170830);grants from the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD 18017);grants from Nature Science Foundation of Department of Science and Technology of Sichuan Province(China)(2023YFS0078).
Type 2 diabetes(T2D)is a disease characterized by heterogeneously progressive loss of isletβcell insulin secretion usually occurring after the presence of insulin resistance(IR)and it is one component of metabolic sy...
关键词：PREVENTION PATHOGENESIS DIAGNOSIS 
What Mice Can Teach Us about How to Stop Drug-Resistant Tuberculosis:Correct Chemotherapy Regimen and Patient Compliance are the Key
《Biomedical and Environmental Sciences》2024年第9期1086-1090,共5页Igor Mokrousov Tatiana Vinogradova Marine Dogonadze Maria Vitovskaya Natalia Zabolotnykh Sergei Chekrygin Anna Vyazovaya 
Despite well-known limitations,mice remain useful as model animals to study tuberculosis(TB)pathogenesis,the basic immune response,the extent of lung pathology as well as efficacy of new drugs against Mycobacterium tu...
关键词：TUBERCULOSIS DRUGS injection 
Primary liver cancer organoids and their application to research and therapy
《Journal of the National Cancer Center》2024年第3期195-202,共8页Xiaobin Zhu Rajiv Trehan Changqing Xie 
funded by the Physician-Scientist Early Investiga-tor Program at CCR of NIH/NCI(grant number:ZIA BC 011888).
Primary liver cancer is a leading cause of death worldwide. To create advanced treatments for primary liver cancer, studies have utilized models such as 2D cell culture and in vivo animal models. Recent developments i...
关键词：Primary liver cancer ORGANOIDS Drug screening TUMORIGENESIS 
Multiple types of disease-associated RNAs identification for disease prognosis and therapy using heterogeneous graph learning
《Science China(Information Sciences)》2024年第8期337-338,共2页Wenxiang ZHANG Hang WEI Wenjing ZHANG Hao WU Bin LIU 
supported by National Natural Science Foundation of China(Grant Nos.62325202,62372041,U22A2039).
Identifying disease-associated RNAs is crucial in revealing the pathogenic mechanisms of diseases[1],and biologists have made notable progress in this field[2].However,more effective computational methods are needed t...
关键词：CONVOLUTION NEURAL network 
Epigenetics and environmental health
《Frontiers of Medicine》2024年第4期571-596,共26页Min Zhang Ting Hu Tianyu Ma Wei Huang Yan Wang 
supported by grants from National Natural Science Foundation of China(Nos.41931291,42125707,82273403);Major State Basic Research Development Program of China(No.2022YFA1103402);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(Nos.2019PT310027 and 2021-RC310-006);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2021-I2M-1-018).
Epigenetic modifications including DNA methylation,histone modifications,chromatin remodeling,and RNA modifications complicate gene regulation and heredity and profoundly impact various physiological and pathological ...
关键词：EPIGENETICS environmental exposure HEALTH prevention and therapy 
Treatment strategy and therapy based on immune response in patients with gastric cancers
《World Journal of Gastrointestinal Surgery》2024年第8期2393-2395,共3页Damian Jacenik Jakub Fichna 
In this editorial,we highlight the significance of a retrospective study“Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis”performed by Liu et al.The au...
关键词：Gastric cancer METASTASIS IMMUNOTHERAPY Treatment strategy 
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