《Translational Neurodegeneration》

作品数：507被引量：1589H指数：15
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《Translational Neurodegeneration》
主办单位：上海交通大学医学院附属瑞金医院；上海交通大学
最新期次：2024年1期更多>>
发文主题：PARKINSONS_DISEASEALZHEIMERS_DISEASENEURODEGENERATIONΑ-SYNUCLEINTAU更多>>
发文领域：医药卫生文化科学理学自动化与计算机技术更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金上海市自然科学基金更多>>
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Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer’s disease models
《Translational Neurodegeneration》2024年第1期200-214,共15页Saige K.Power Sridevi Venkatesan Sarah Qu JoAnne McLaurin Evelyn K.Lambe 
funded by research grants from the Canadian Institutes of Health(CIHR):MOP 89825,EKL;PRJ153101,EKL and JM;support of a CIHR Banting and Best Canada Graduate Scholarship and an Ontario Graduate Scholarship,SKP.
Background Cognitive reserve allows for resilience to neuropathology,potentially through active compensation.Here,we examine ex vivo electrophysiological evidence for active compensation in Alzheimer’s disease(AD)foc...
关键词：Alzheimer’s disease Cognitive reserve Prefrontal cortex ACETYLCHOLINE Nicotinic receptors OPTOGENETICS ELECTROPHYSIOLOGY Acetylcholinesterase inhibitor Compensation 
Aquaporin-4 as a cerebrospinal fluid biomarker of Alzheimer’s disease
《Translational Neurodegeneration》2024年第1期215-218,共4页Nerea Gómez de San José Steffen Halbgebauer Petra Steinacker Sarah Anderl-Straub Samir Abu-Rumeileh Lorenzo Barba Patrick Oeckl Giovanni Bellomo Lorenzo Gaetani Andrea Toja Sára Mravinacová Sofia Bergström Anna Månberg Alberto Grassini Innocenzo Rainero Peter Nilsson Lucilla Parnetti Markus Otto 
MO,LP,PN SM and NGSJ are supported by the Marie Skłodowska-Curie grant agreement No.860197—MIRIADE project(European Union’s Horizon 2020 research and innovation program);GB is supported by the Postdoctoral Fellowship for Basic Scientists grant of the Parkinson’s Foundation(Award ID:PF-PRF-934916);LP and LG are funded by the European Union—Next Generation EU—PNRR M6C2—Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica del SSN(PNRR-MAD-2022–12376035);LB is supported by the Medical Faculty of Martin-Luther University Halle Wittenberg(Junior Clinician Scientist Programm No.JCS24/02);SAB received research support from the Medical Faculty of Martin-Luther University Halle-Wittenberg(Clinician Scientist-Programm No.CS22/06).
The diagnosis of Alzheimer’s disease(AD)relies on the clinical evaluation of patients,often complemented by the analysis of core cerebrospinal fluid(CSF)biomark-ers(Aβ42/40,phosphorylated-Tau and total-tau)[1].Howev...
关键词：CEREBROSPINAL fluid ALZHEIMER TAU diagnosis Aβ 
Tau in neurodegenerative diseases:molecular mechanisms,biomarkers,and therapeutic strategies
《Translational Neurodegeneration》2024年第1期513-529,共17页Xingyu Zhang Jiangyu Wang Zhentao Zhang Keqiang Ye 
supported by grants from the National Key Basic Research Program of China(2019YFE0115900 to Z.Z.);the National Natural Science Foundation of China(81822016,81771382 to Z.Z.,82301356 to X.Z.,32330040,82350710222 to K.Y.).
The deposition of abnormal tau protein is characteristic of Alzheimer’s disease(AD)and a class of neurodegenerative diseases called tauopathies.Physiologically,tau maintains an intrinsically disordered structure and ...
关键词：TAU Alzheimer’s disease TAUOPATHIES AGGREGATION PROPAGATION Biomarkers 
Neuronal double-stranded DNA accumulation induced by DNase II deficiency drives tau phosphorylation and neurodegeneration
《Translational Neurodegeneration》2024年第1期530-546,共17页Ling-Jie Li Xiao-Ying Sun Ya-Ru Huang Shuai Lu Yu-Ming Xu Jing Yang Xi-Xiu Xie Jie Zhu Xiao-Yun Niu Dan Wang Shi-Yu Liang Xiao-Yu Du Sheng-Jie Hou Xiao-Lin Yu Rui-Tian Liu 
supported by funding from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39050600);the National Natural Science Foundation of China(82150107 and 81971073);the National Key Research and Development Program of China(2020YFA0712402).
Background Deoxyribonuclease 2(DNaseⅡ)plays a key role in clearing cytoplasmic double-stranded DNA(dsDNA).Deficiency of DNaseⅡleads to DNA accumulation in the cytoplasm.Persistent dsDNA in neurons is an early pathol...
关键词：DNaseⅡ Alzheimer’s disease Double-stranded DNA Tau phosphorylation TAUOPATHY 
Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer’s disease
《Translational Neurodegeneration》2024年第1期547-550,共4页Hao Huang Rong Xiang Riqiang Yan 
supported by the National Natural Science Foundation of China(82300787,82170598);the Hunan Provincial Key Field R&D Plan Project(2022SK2034);the Natural Science Foundation of Hunan Province(2022JJ30058);the Youth Science Foundation of Xiangya Hospital(2021Q11).
Alzheimer’s disease(AD)is characterized by progressive cognitive decline and is a neurodegenerative disorder that primarily affects the elderly population worldwide.The main neuropathological features of AD include t...
关键词：Alzheimer AMYLOID SPITE 
Blood-brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy被引量：2
《Translational Neurodegeneration》2024年第1期551-574,共24页Kristina Lau Rebecca Kotzur Franziska Richter 
funded by intramural funds with no role in writing of the manuscript.
There is increasing evidence for blood-brain barrier(BBB)alterations in Parkinson’s disease(PD),the second most common neurodegenerative disorder with rapidly rising prevalence.Altered tight junction and transporter ...
关键词：Neurovascular unit SYNUCLEINOPATHIES Α-SYNUCLEIN 
The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases
《Translational Neurodegeneration》2024年第1期1023-1034,共12页Arazu Sharif John Mamo Virginie Lam Hani Al-Salami Armin Mooranian Gerald F.Watts Roger Clarnette Giuseppe Luna Ryu Takechi 
supported by the National Health and Medical Research Council of Australia(GNT2001090);Medical Research Future Fund(MRF1201204),MSWA,McCusker Charitable Research Foundation and the Wen Giving Foundation.
Neurodegenerative disorders present complex pathologies characterized by various interconnected factors,including the aggregation of misfolded proteins,oxidative stress,neuroinflammation and compromised blood-brain ba...
关键词：Neurodegenerative disease PROBUCOL Probucol analogues INFLAMMATION Blood-brain barrier Oxidative stress INFLAMMATION AMYLOID-BETA 
Correction:A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau
《Translational Neurodegeneration》2024年第1期1035-1037,共3页Yang Gao Yuying Wang Huiyang Lei Zhendong Xu Shihong Li Haitao Yu Jiazhao Xie Zhentao Zhang Gongping Liu Yao Zhang Jie Zheng Jian-Zhi Wang 
Correction:Translational Neurodegeneration 12:51(2023)https://doi.org/10.1186/s40035-023-00379-5 Following publication of the original article[1],the authors reported an error in the Fig.2:Figure 2e presented a typing...
关键词：FIGURE corrected WRONG 
Death-associated protein kinase 1 as a therapeutic target for Alzheimer’s disease
《Translational Neurodegeneration》2024年第1期1038-1063,共26页Tao Zhang Byeong Mo Kim Tae Ho Lee 
supported by the National Natural Science Foundation of China(82271449 and 81970993)to T.H.Lee;T.Zhang receives financial support from the National Natural Science Foundation of China(82001128);the Natural Science Foundation of Fujian Province(2021J01672).
Alzheimer’s disease(AD)is the most prevalent form of dementia in the elderly and represents a major clinical challenge in the ageing society.Neuropathological hallmarks of AD include neurofibrillary tangles composed ...
关键词：Death-associated protein kinase 1 Alzheimer’s disease TAU Amyloid-β Neuronal cell death Therapeutic target 
Increased cysteinyl-tRNA synthetase drives neuroinflammation in Alzheimer’s disease被引量：1
《Translational Neurodegeneration》2024年第1期1064-1082,共19页Xiu-Hong Qi Peng Chen Yue-Ju Wang Zhe-Ping Zhou Xue-Chun Liu Hui Fang Chen-Wei Wang Ji Liu Rong-Yu Liu Han-Kui Liu Zhen-Xin Zhang Jiang-Ning Zhou 
supported by the National Natural Science Foundation of China(32030046,32000716);the Strategic Priority Research Program of the Chinese Academy of Science(XDB32020200);the National Key R&D Program of China(2016YFC1305900);the STI2030-Major Projects(2022ZD0205202);Anhui Province University Scientific Research Project(KJ2021A0212).
Background Microglia-mediated neuroinflammation in Alzheimer’s disease(AD)is not only a response to pathophysiological events,but also plays a causative role in neurodegeneration.Cytoplasmic cysteinyl-tRNA synthetase...
关键词：Cysteinyl-tRNA synthetase Alzheimer’s disease NEUROINFLAMMATION MICROGLIA TLR2 
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