supported by National Institutes of Health Grants R21-AG048506,P01-AG000538 and RO1-AG34667(to CWC);UC MEXUS-CONACYT Grant CN-16-170(to GAP and CWC)
Synapses are essential units for the flow of information in the brain.Over the last 70 years,synapses have been widely studied in multiple animal models including worms,fruit flies,and rodents.In comparison,the study ...
supported by the Research Council of Khorasgan Branch,Islamic Azad University,Isfahan.
Tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosynthesis of dopamine and serotonin,respectively.Since both enzymes are active in striatum,and affected by age,this study was und...
Aim: Excessive glutamate release has been proposed to be involved in the pathogenesis of several neurological diseases. In this study, we investigated the effect of HDT-1 (3, 4, 4a, 5, 8, 8a-hexahydro-6,7-dimethyl-...
the Major State Basic Research Development Program of China (973 pro-gram), No. G1999054000; the National Natural Science Foun-dation of China, No. 30170302;Basic Research Program of Shanghai, No. 02JC14011
BACKGROUND: Toosendanin (TSN), a tnterpenoid derivative extracted from the bark of Melia toosendanin Sieb et Zucc, has been demonstrated to be an effective drug for treatment of experimental botulism. OBJECTIVE : ...
To investigate the effect of propofol on the release of glutamate and γ-aminobutyric acid (GABA) from rat hippocampal synatosomes, synaptosomes was made from hippocampus and incubated with artificial cerebrospinal ...
Summary: To investigate the effect of thiopental sodium on the release of glutamate and γ-aminobutyric acid (GABA) from synaptosomes in the prefrontal cortex, synaptosomes were made, the spontaneous release and the e...
Project partly supported by the Ministry of Science and Technology of China (2001BA310A07).
AIM: To evaluate the effects of scutellarin on superoxide-induced oxidative stress in rat cortical synaptosomes. METHODS: Oxidative damage model was established by incubation with xanthine(0.3 mmol/L) and xanthine o...
increase in total PTK and Src activities induced by I/R may be mediated via NR and L-type VGCC. The PTP activity did not change during I/R.To study the changes and mechanisms of protein-tyrosine kinase (PTK) and prote...
Project supported by the National Natural Science Foundation of China (Grant No. 39330100).
The effects of glucocorticoids on the Na+-dependent, high affinity uptake of 3[H]-L-glutamate in synaptosomes from cerebral cortex of rats were investigated. Glucocorticoids, including corticosterone (B), cortices ter...