supported by the Israel Science Foundation(ISF grant 1994/21 and 3252/21);Zuckerman(Zuckerman STEM leadership program)(to SS).
Parkinson’s disease(PD)was first described as a neurological disease by Dr.James Parkinson in 1817 as a“shaking palsy”.Since that time,much more is known about the pathophysiology of PD yet the disease is still unc...
This work was supported by grants from Junta de Extremadura,Spain,No.IB18048(to EAC),the ONCE Foundation(to GMC);the Isabel Gemio Foundation(to SMSYD);the Instituto de Salud Carlos III,CIBERNED,No.CB06/05/004(to JMF);partially supported by the“Fondo Europeo de Desarrollo Regional”(FEDER)from the European Union.
Neuronal cell death is the main hallmark of Parkinson’s disease(PD).It is an irreversible process promoted by neurotoxins and/or genetic mutations.Different types of cell death have been associated with PD.The mechan...
The original article titled"Establishment of a Parkinson’s disease model in rats via striatal one-site double injection:Feasibility observation’published in Neural Regeneration Research(Liu et al.,2008a),is being re...
supported by the Ministerio de Economia y Competitividad(MAT2016-79832-R,to DGN);the Community of Madrid(Neurocentro-B2017/BMD-3760,to DGN)
The neurological devastation of neurodegenerative and cerebrovascular diseases reinforces our perseverance to find advanced treatments to deal with these fatal pathologies.High-performance preclinical results have fai...
supported by the National Natural Science Foundation of China,No.81471288(to WLL);the National High Technology Research and Development Program of China(863 Program),No.2017YFA0104704(to WLL)
Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function,and also regulate pathological processes in brain diseases and injury.However,the role of astrocytes in the dopamine-...
supported by the National Research Foundation of Korea,grant No.2016R1D1A3B03930722(to MKL),Republic of Korea
Gynostemma(G.) pentaphyllum(Cucurbitaceae) contains various bioactive gypenosides. Ethanol extract from G. pentaphyllum(GP-EX) has been shown to have ameliorative effects on the death of dopaminergic neurons in animal...
supported by the National Natural Science Foundation of China,No.81241126(to XLD)and 81360197(to XLD);a grant from the Department of Science and Technology of Kunming Medical University in China,No.2013C227(to XLD);the Joint Special Fund for the Department of Science and Technology of Kunming Medical University in China,No.2014FB041(to XBS)
Previous studies have shown that neural stem cell transplantation has the potential to treat Parkinson’s disease,but its specific mechanism of action is still unclear.Stromal cell-derived factor-1 and its receptor,ch...
What is the rationale for immunotherapies in Parkinsonian syndromes (PS)? PS are neurodegenerative diseases which are clinically characterized by a hypokinetic phenotype in combination with additional motor and non-mo...
supported by the Natural Science Foundation of Beijing of China,No.7192235(to LKX)
Artemisinin,also called qinghaosu,is originally derived from the sweet wormwood plant(Artemisia annua),which is used in traditional Chinese medicine.Artemisinin and its derivatives(artemisinins)have been widely used f...
Common neurodegenerative diseases of the central nervous system are characterized by progressive damage to the function of neurons, even leading to the permanent loss of function. Gene therapy via gene replacement or ...