COGNITIVE

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Resilience to structural and molecular changes in excitatory synapses in the hippocampus contributes to cognitive function recovery in Tg2576 mice
《Neural Regeneration Research》2024年第9期2068-2074,共7页Carolina Aguado Sara Badesso JoséMartínez-Hernández Alejandro Martín-Belmonte Rocío Alfaro-Ruiz Miriam Fernández Ana Esther Moreno-Martínez Mar Cuadrado-Tejedor Ana García-Osta Rafael Luján 
supported by grant PID2021-125875OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by"ERDF A way of making Europe"(to RL);supported by a grant from Junta de Comunidades de Castilla-La Mancha (SBPLY/21/180501/000064);Universidad de Castilla-La Mancha (2023-GRIN-34187)(to RL).Grant PID201 9-104921RB-I00/MCI/AEI/10.13039/501100011033 (to AGO);the Foundation for Applied Medical Research,the University of Navarra (Pamplona,Spain)for financial support;he Asociación de Amigos of the University of Navarra for the grant (to SB);Margarita Salas fellowship from Ministerio de Universidades and Universidad de Castilla-La Mancha (to AMB)
Plaques of amyloid-β(Aβ)and neurofibrillary tangles are the main pathological characteristics of Alzheimer’s disease(AD).However,some older adult people with AD pathological hallmarks can retain cognitive function....
关键词：aging Alzheimer´s disease COGNITIVE HIPPOCAMPUS immunoelectron microscopy RESILIENCE SYNAPSE 
Latest assessment methods for mitochondrial homeostasis in cognitive diseases被引量：3
《Neural Regeneration Research》2024年第4期754-768,共15页Wei You Yue Li Kaixi Liu Xinning Mi Yitong Li Xiangyang Guo Zhengqian Li 
supported by the National Natural Science Foundation of China,Nos.82271222(to ZL),81971012(to ZL),82071189(to XG),and 82201335(to YL);Key Clinical Projects of Peking University Third Hospital,No.BYSYZD2019027(to ZL)。
Mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,sub...
关键词：cognitive disorders mitochondrial dysfunction mitochondrial energy metabolism mitochondrial dynamics mitochondrial transport MITOPHAGY mitochondrial biogenesis oxidative stress calcium homeostasis 
β2-Microglobulin exacerbates neuroinflammation,brain damage,and cognitive impairment after stroke in rats被引量：13
《Neural Regeneration Research》2023年第3期603-608,共6页Feng Chen Jing Liu Fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu Fang-Fang Hu Rui-Qin Yao 
supported by the National Natural Science Foundation of China,No.81771337(to RQY).
β2-Microglobulin(β2M),a component of the major histocompatibility complex class I molecule,is associated with aging-related cognitive impairment and Alzheimer’s disease.Although upregulation ofβ2M is considered to...
关键词：cognitive impairment cognitive improvement glial activation infarct volume ISCHEMIA middle cerebral artery occlusion NEUROINFLAMMATION NLRP3 inflammasome STROKE β2 microglobulin 
Targeting mechanisms in cognitive training for neurodegenerative diseases
《Neural Regeneration Research》2021年第3期500-501,共2页Annalena Venneri Riccardo Manca Linford Fernandes Oliver Bandmann Matteo De Marco 
"Cognitive training"(CT)is a label used to describe paper-and-pen or computerized exercises designed to engage a desired set of mental skills for the purpose of enhancing neurocognitive functioning.Although the litera...
关键词：DESIRED considerably COGNITIVE 
Neural plasticity secondary to carpal tunnel syndrome: a pseudo-continuous arterial spin labeling study
《Neural Regeneration Research》2021年第1期158-165,共8页Xue Deng Phoebe Lai-Heung Chau Suk-Yee Chiu Kwok-Pui Leung Yong Hu Wing-Yuk Ip 
Conventional neuroimaging techniques cannot truly reflect the change of regional cerebral blood flow in patients with carpal tunnel syndrome.Pseudo-continuous arterial spinning labeling(pCASL)as an efficient non-invas...
关键词：Boston carpal tunnel questionnaire carpal tunnel syndrome COGNITIVE nerve conduction studies PAIN principal component analysis pseudo-continuous arterial spin labeling 
Jidong cognitive impairment cohort study: objectives, design, and baseline screening被引量：1
《Neural Regeneration Research》2020年第6期1111-1119,共9页Dai-Yu Song Xian-Wei Wang Sa Wang Si-Qi Ge Guo-Yong Ding Xue-Yu Chen Yan-Ru Chen Hua-Min Liu Xiao-Mei Xie Wei-Jia Xing Dong Li Yong Zhou 
supported by the National Natural Science Foundation of China,No.91749205(to YZ),81973112(to YZ),81973138(to DL),81903401(to WJX);the Young Taishan Scholars Program of Shandong Province of China,No.tsqn20161046(to WJX)
The risk of dementia increases in patients with cognitive impairment.However,it is not clear what factors contribute to the onset of dementia in those with cognitive impairment.In this prospective cohort study,we will...
关键词：assessment COGNITIVE IMPAIRMENT community DEMENTIA FOLLOW-UP Mini-Mental Status Examination Scale model new basis prevention PROGNOSTIC factors 
Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease被引量：28
《Neural Regeneration Research》2019年第9期1626-1634,共9页Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre 
sponsored by CONACYT scholarship#487713;Fondo Mixto de Ciencia y Tecnología del Estado de Jalisco grant JAL-2014-0-250508
Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived e...
关键词：Alzheimer’s DISEASE neurodegenerative DISEASE COGNITIVE impairment memory Alzheimer’s DISEASE MOUSE model mesenchymal stem cell EXOSOMES NEUROGENESIS COGNITIVE improvement cell-free therapy neural regeneration 
Impacting dementia and cognitive loss with innovative strategies: mechanistic target of rapamycin, clock genes, circular non-coding ribonucleic acids, and Rho/Rock被引量：5
《Neural Regeneration Research》2019年第5期773-774,共2页Kenneth Maiese 
A significant global impact from dementia:According to the World Health Organization(Dua et al.,2017),the current numbers for the prevalence and treatment costs for dementia worldwide are staggering.Almost 50 million ...
关键词：Impacting DEMENTIA COGNITIVE LOSS INNOVATIVE strategies 
An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice被引量：15
《Neural Regeneration Research》2019年第3期462-469,共8页Chuan-Jie Wang Yi Wu Qun Zhang Ke-Wei Yu Yu-Yang Wang 
supported by the National Natural Science Foundation of China,No.81672242(to YW);the Key Construction Projects of Shanghai Health and Family Planning on Weak Discipline,China,No.2015ZB0401(to YW)
Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental enrichment on spatial learning and memory as well as on syn...
关键词：nerve REGENERATION environmental enrichment CEREBRAL ischemia COGNITIVE RECOVERY brain PLASTICITY and reorganization synaptic PLASTICITY electron microscopy growth-associated PROTEIN 43 synaptophysin postsynaptic density PROTEIN 95 permanent middle CEREBRAL artery occlusion neural REGENERATION 
Regional gray matter atrophy and neuropsychologcal problems in relapsing-remitting multiple sclerosis
《Neural Regeneration Research》2013年第21期1958-1965,共8页Aiyu Lin Fuyong Chen Fang Liu Zhiwen Li Ying Liu Shifang Lin Xiaoyi Wang Jiting Zhu 
In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encountered. It has been conjectured that focal atrophy is associated with emotional decline. However, ...
关键词：neural regeneration NEURODEGENERATION MRI relapsing-remitting multiple sclerosis gray matter atrophy COGNITIVE MOOD voxel-based morphometry NEUROREGENERATION 
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