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NECAB family of neuronal calcium-binding proteins in health and disease
《Neural Regeneration Research》2025年第5期1236-1243,共8页Diones Bueno Michael K.E.Schafer Sudena Wang Michael J.Schmeisser Axel Methner 
supported by the Deutsche Forschungsgemeinschaft (ME1922/14-1) to AM。
The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally le...
关键词：CALCIUM EF hand MITOCHONDRIA nervous system signal transduction 
Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions
《Neural Regeneration Research》2025年第4期1031-1041,共11页Ramón Pérez-Núñez María Fernanda González Ana María Avalos Lisette Leyton 
supported by Fondo Nacional de Desarrollo Científico y Tecnológico(FONDECYT)#1200836,#1210644,and#1240888,and Agencia Nacional de Investigación y Desarrollo(ANID)-FONDAP#15130011(to LL);FONDECYT#3230227(to MFG).
Astrocytes are the most abundant type of glial cell in the central nervous system.Upon injury and inflammation,astrocytes become reactive and undergo morphological and functional changes.Depending on their phenotypic ...
关键词：inflammation INTEGRINS NEUROPROTECTIVE NEUROTOXIC phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(CD90) 
Na^(+)/K^(+)-ATPase:ion pump,signal transducer,or cytoprotective protein,and novel biological functions被引量：2
《Neural Regeneration Research》2024年第12期2684-2697,共14页Songqiang Huang Wanting Dong Xiaoqian Lin Jinsong Bian 
supported by the National Natural Science Foundation of China,No.82173800 (to JB);Shenzhen Science and Technology Program,No.KQTD20200820113040070 (to JB)。
Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^...
关键词：ANTIBODY biological functions cellular communication electrochemical gradient ion balance ion channels Na^(+)/K^(+)-ATPase neurological diseases neurotransmitter release signal transduction 
Downregulation of signal transduction and STAT3 expression exacerbates oxidative stress mediated by NLRP3 inflammasome被引量：2
《Neural Regeneration Research》2018年第12期2147-2155,共9页Hua Bai Qi-Fang Zhang Juan-Juan Duan De-Jun Yu Li-Jie Liu 
supported by Department of Science and Technology in Guizhou Province of China,No.Basic [2016]1131(to QianKe-He; to HB);Department of Health and Family Planning Commission in Guizhou Province of China,No.2015-326(to HB);Less Developed Regions of the National Natural Science Foundation of China,No.81560482;the Research Foundation for Creative Research Groups of Education Bureau of Guizhou Province of China,No.KY[2016]033(to QFZ)
Activated nucleotide binding to the oligonucleotide receptor protein 3（NLRP3） inflammasome is possibly involved in the pathogenesis of Alzheimer＇s disease through oxidative stress and neurogenic inflammation. Low e...
关键词：nerve regeneration signal transducer and activator of transcription 3 calcium caspase-l nucleotide binding to the oligonucleotide receptor protein 3 INFLAMMASOME hydrogen peroxide Alzheimer＇s disease shRNA SHSYSY cells neural regeneration 
Ca^(2＋) involvement in activation of extracellular-signal- regulated-kinase 1/2 and m-calpain after axotomy of the sciatic nerve被引量：4
《Neural Regeneration Research》2017年第4期623-628,共6页Lisa B. Martensson Charlotta Lindwall Blom Lars B. Dahlin 
supported by the Research School in Pharmaceutical Science in Lund,The Royal Physiographic Society in Lund;The Swedish Research Council(Medicine);the Craaford’s and Thure Nilsson’s Funds for Medical Research;Funds for diabetic research,Lund University and Region Skane
Detailed mechanisms behind regeneration after nerve injury, in particular signal transduction and the fate of Schwann cells （SCs）, are poorly understood. Here, we investigated axotomy-induced activation of extracell...
关键词：nerve regeneration P-ERK1/2 M-CALPAIN nerve injury signal transduction cell proliferation cell death ACTIVATION AXOTOMY sciatic nerve neural regeneration 
Manual acupuncture at the SJ5(Waiguan) acupoint shows neuroprotective effects by regulating expression of the anti-apoptotic gene Bcl-2被引量：2
《Neural Regeneration Research》2016年第2期305-311,共7页Dong Lin Li-li Lin Kyle Sutherland Chuan-hai Cao 
supported by the National Natural Science Foundation of China,No.81273672,81373720;the Natural Science Foundation of Fujian Province of China,No.2014J01353;a grant from Fujian Province Health Planning Commission Project(2014)for Training Young Talents,No.2014-ZQN-JC-28
Acupuncture at the SJ5（Waiguan） acupoint has neuroprotective effects in cerebral infarction, but the underlying mechanism remains poorly understood. Here, we analyzed gene expression in healthy rat cerebellum using ...
关键词：nerve regeneration NEUROPROTECTION acupuncture SJ5 CEREBELLUM apoptosis signal transduction BCL-2 neural regeneration 
Factors affecting directional migration of bone marrow mesenchymal stem cells to the injured spinal cord被引量：3
《Neural Regeneration Research》2014年第18期1688-1695,共8页Peng Xia Su Pan Jieping Cheng Maoguang Yang Zhiping Qi Tingting Hou Xiaoyu Yang 
supported by the National Natural Science Foundation of China,No.81350013,81250016;the Youth Science Project of National Natural Science Foundation of China,No.81301289;the Youth Scientific Research Project of Jilin Provincial Science and Technology Development Plan,No.20130522032JH,20130522039JH
Microtubule-associated protein 1B plays an important role in axon guidance and neuronal migration. In the present study, we sought to discover the mechanisms underlying microtu- bule-associated protein 1B mediation of...
关键词：nerve regeneration bone marrow mesenchymal stem cells spinal cord injury microtubule-associated protein 1 B protein phosphatase 2A cell transplantation PHOSPHORYLATION signal transduction NSFC grant neural regeneration 
Mannotriose regulates learning and memory signal transduction in the hippocampus被引量：1
《Neural Regeneration Research》2013年第32期3020-3026,共7页Lina Zhang Weiwei Dai Xueli Zhang Zhangbin Gong Guoqin Jin 
financially supported by the National Natural Science Foundation of China,No.30873317;the Leading Academic Discipline Project of Shanghai Municipal Education Commission,No.J50301;"085 Class Disciplines Building"Scientific and Technology Innovation Fundation,No.085ZY1204;Shanghai Health Bureau of Scientific Research Projects,No.20124Y025
Rehmannia is a commonly used Chinese herb, which improves ieaming and memory. However, the crucial components of the signal transduction pathway associated with this effect remain elusive. Pri- mary hippocampal neuron...
关键词：neural regeneration traditional Chinese medicine REHMANNIA mannotriose CORTICOSTERONE HIPPOCAMPUS neurons learning and memory grants-supported paper NEUROREGENERATION 
Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway
《Neural Regeneration Research》2012年第28期2189-2198,共10页Heping Yang Dapeng Wu Xiaojie Zhang Xiang Wang Yi Peng Zhiping Hu 
supported by a grant under Key Projects of Guangxi Traditional Chinese Medical University, No.ZD2007041
Telencephalin is a neural glycoprotein that reduces apoptosis induced by amyloid beta protein in the human neural tumor cell line PAJU. In this study, we examined the role of the ezrin/radixin/moesin protein family/ph...
关键词：telencephalin/intercellular adhesion molecule 5 amyloid beta protein ezrin/radixin/moesin familyproteins/phosphatidylinositol-3-kinase/protein kinase B signal transduction neural regeneration 
Effects of Zhichan powder on signal transduction and apoptosis-associated gene expression in the substantia nigra of Parkinson's disease rats被引量：1
《Neural Regeneration Research》2012年第27期2115-2122,共8页Jiajun Chen Jinshu Ma Yafei Qiu Shihong Yi Yongmao Liu Qingwei Zhou PengguoZhang Quan Wan Ye Kuang 
Previous studies have shown that Zhichan powder elevated immunity and suppressed oxidation in mice. Rat models of Parkinson＇s disease were induced by stereotaxically injecting 6-hydroxydopamine into the substantia ni...
关键词：Zhichan powder Parkinson＇s disease 6-HYDROXYDOPAMINE signal transduction APOPTOSIS substantia nigra traditional Chinese medicine degenerative disease neural regeneration 
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