CENTRAL_NERVOUS_SYSTEM

作品数:499被引量:1548H指数:18
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相关机构:苏州大学广州医学院第二附属医院浙江大学中国海洋大学更多>>
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FIREproof:Intricacies of microglial biology
《Neural Regeneration Research》2026年第2期663-664,共2页Wei Cao 
funded by NIH grants HL154720-03S1,AG057587,AG074283,DK122708-03S1,BrightFocus ADR A20183775,and Brown Foundation 2020 Healthy Aging Initiative(to WC).
Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases....
关键词:neurological diseases facilitating neurogenesis debris removal central nervous systemincluding NEUROGENESIS MYELINATION synapse pruning brain 
Fibrotic scar formation after cerebral ischemic stroke:Targeting the Sonic hedgehog signaling pathway for scar reduction
《Neural Regeneration Research》2026年第2期756-768,共13页un Wen Hao Tang Mingfen Tian Ling Wang Qinghuan Yang Yong Zhao Xuemei Li Yu Ren Jiani Wang Li Zhou Yongjun Tan Haiyun Wu Xinrui Cai Yilin Wang Hui Cao Jianfeng Xu Qin Yang 
supported by the National Natural Science Foundation of China,Nos.82171456(to QY)and 81971229(to QY);the Natural Science Foundation of Chongqing,Nos.CSTC2021JCYJ-MSXMX0263(to QY)and CSTB2023NSCQ-MSX1015(to XL);Doctoral Innovation Project of The First Affiliated Hospital of Chongqing Medical University,Nos.CYYY-BSYJSCXXM-202318(to JW)and CYYY-BSYJSCXXM-202327(to HT).
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment.However,little is known about how fibrosis is induced and regulated after...
关键词:central nervous system FIBROBLASTS fibrosis ischemic stroke Mitofusin 2 middle cerebral artery occlusion/reperfusion P-Smad3 Sonic Hedgehog SMAD3 TOM20 
Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury
《Neural Regeneration Research》2026年第1期39-56,共18页Liping Shi Shuyi Liu Jialing Chen Hong Wang Zhengbo Wang 
supported by the Natural Science Foundation of Yunnan Province,No.202401AS070086(to ZW);the National Key Research and Development Program of China,No.2018YFA0801403(to ZW);Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(to ZW);the Natural Science Foundation of China,No.31960120(to ZW)。
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl...
关键词:animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell MICROGLIA NEUROINFLAMMATION non-human primate signaling pathway traumatic brain injury 
Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury
《Neural Regeneration Research》2025年第11期3063-3075,共13页Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant 
supported by Ohio State Start Up Fund;National Institutes of Health(NIH);Department of Defense(DoD);Wings for Life Spinal Cord Research Foundation,Wings for Life Spinal Cord Research Foundation(Austria);California Institute of Regenerative Medicine(CIRM);International Spinal Research Trust(United Kingdom);Stanford University Bio-X Program Interdisciplinary Initiatives Seed Grant IIP-7;Dennis Chan Foundation;Klein Family Fund;Lucile Packard Foundation for Children's Health;Stanford Institute for Neuro-Innovation and Translational Neurosciences(SINTN);Saunders Family Neuroscience Fund;James Doty Neurosurgery Fund;Hearst Neuroscience Fund;Eileen Bond Research Fund(to GP)。
In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative medicine.Considering the non-regenerative nature of the mature central nervous system,the c...
关键词:axon regeneration central nervous system regeneration induced pluripotent stem cells NEUROTRAUMA regenerative medicine spinal cord injury stem cell therapy 
Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system
《Neural Regeneration Research》2025年第11期3209-3210,共2页Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell 
supported by Grants from Spanish FEDER/Science and Innovation Ministry I+D+i-RETOS-PID2021-124801NB-100;Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas(CIBERN ED;an initiative of the ISCIII)[PI2016/01];the Fundocion Ramon Areces and Banco Santander to the CBMSO(to FW)。
Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and function.This cellular process is evolutionarily highly conserved to quality control of many pr...
关键词:HOMEOSTASIS SYSTEM hereafter 
Role of resident memory T cells in neuroinflammatory and neurodegenerative diseases in the central nervous system
《Neural Regeneration Research》2025年第11期3227-3228,共2页Kimitoshi Kimura 
The immune system has been attracting increasing attention in the field of chronic neurological disorders in the central nervous system(CNS).Autoreactive T cells targeting CNS antigens play a crucial role in the devel...
关键词:DISEASES DEGENERATIVE PATHOLOGY 
Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury
《Neural Regeneration Research》2025年第10期2807-2822,共16页Xizi Song Ruixin Li Xiaolei Chu Qi Li Ruihua Li Qingwen Li Kai-Yu Tong Xiaosong Gu Dong Ming 
supported by grants from the Natural Science Foundation of Tianjin(General Program),Nos.23JCYBJC01390(to RL),22JCYBJC00220(to XC),and 22JCYBJC00210(to QL).
Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and disabilities.Research on the pathogenesis of peripheral nerve injury has focused on pathological changes...
关键词:central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach 
Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials
《Neural Regeneration Research》2025年第9期2437-2453,共17页Siyi Xu Junqiu Jia Rui Mao Xiang Cao Yun Xu 
supported by the National Natural Science Foundation of China,Nos.81920108017(to YX),82130036(to YX),82371326(to XC),82171310(to XC);the STI2030-Major Projects,No.2022ZD0211800(to YX);Jiangsu Province Key Medical Discipline,No.ZDXK202216(to YX)。
Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal ...
关键词:autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control MITOPHAGY spinal cord injury subarachnoid hemorrhage traumatic brain injury 
Olfactory receptors in neural regeneration in the central nervous system
《Neural Regeneration Research》2025年第9期2480-2494,共15页Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo 
Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional memories.These receptors also contribute to our perception of flavor...
关键词:adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors GLIA NEURONS 
Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier
《Neural Regeneration Research》2025年第8期2133-2152,共20页Yilun Ma Taiwei Dong Fei Luan Juanjuan Yang Feng Miao Peifeng Wei 
supported by the National Natural Science Foundation of China,No.82104412(to TD);Shaanxi Provincial Key R&D Program,No.2023-YBSF-165(to TD);the Natural Science Foundation of Shaanxi Department of Science and Technology,No.2018JM7022(to FM);Shaanxi Provincial Key Industry Chain Project,No.2021ZDLSF04-11(to PW)。
The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the bloo...
关键词:blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells LYSOPHOSPHATIDYLCHOLINE major facilitator superfamily domain containing 2A(MFSD2A) TRANSCYTOSIS 
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