EXTRACELLULAR_MATRIX

作品数：418被引量：1435H指数：17
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Neurocircuit regeneration by extracellular matrix reprogramming
《Neural Regeneration Research》2025年第8期2300-2301,共2页Shengzhang Su Ian N.Levasseur Kimberly M.Alonge 
supported by National Institute on Aging(NIH-NIA)R21 AG074152(to KMA);National Institute of Allergy and Infectious Diseases(NIAID)grant DP2 AI171150(to KMA);Department of Defense(DoD)grant AZ210089(to KMA)。
The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20%-40% of the human brain and is considered one of the largest influencers on brain cell functioning...
关键词：MATRIX PROGRAMMING 
Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration
《Neural Regeneration Research》2025年第5期1364-1376,共13页Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan Juan Xing 
supported by the Natio`nal Natural Science Foundation of China,No. 81801241;a grant from Sichuan Science and Technology Program,No. 2023NSFSC1578;Scientific Research Projects of Southwest Medical University,No. 2022ZD002 (all to JX)。
Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to p...
关键词：ALGINATE axon growth BIOMATERIALS extracellular matrix neural repair neurons NEUROREGENERATION POLYACRYLAMIDE POLYDIMETHYLSILOXANE stiffness 
Transcriptomic analysis of spinal cord regeneration after injury in Cynops orientalis被引量：1
《Neural Regeneration Research》2023年第12期2743-2750,共8页Di Wang Man Zhao Xiao Tang Man Gao Wenjing Liu Minghui Xiang Jian Ruan Jie Chen Bin Long Jun Li 
the National Natural Science Foundation of China,Nos.32270516,31970413;the Natural Science Foundation of Anhui Province,No.1908085MC83(to JL);a Start-up grant from Nanjing Agricultural University,No.804090。
Cynops orientalis(C.orientalis)has a pronounced ability to regenerate its spinal cord after injury.Thus,exploring the molecular mechanism of this process could provide new approaches for promoting mammalian spinal cor...
关键词：Cynops orientalis extracellular matrix glial fibrillary acidic protein METABOLISM NEURON RNA sequence SALAMANDER spinal cord injury spinal cord regeneration TRANSCRIPTOMICS 
M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats被引量：2
《Neural Regeneration Research》2023年第10期2208-2218,共11页Jia-Gui Huang Jiang-Xia Ren Yue Chen Ming-Fen Tian Li Zhou Jun Wen Xiao-Song Song You-Lin Wu Qing-Huan Yang Pei-Ran Jiang Jia-Ni Wang Qin Yang 
supported by the National Natural Science Foundation of China,Nos.82171456 (to QY),81971229 (to QY);the Natural Science Foundation of Chongqing,No.cstc2021jcyj-msxmX0263 (to QY);the Postgraduate Research and Innovation Project of Chongqing,Nos.CYB20151 (to QY),CYS19182 (to YC)。
In the central nervous system, the formation of fibrotic scar after injury inhibits axon regeneration and promotes repair. However, the mechanism underlying fibrotic scar formation and regulation remains poorly unders...
关键词：central nervous system extracellular matrix FIBRONECTIN fibrotic scar macrophage interleukin 4 ischemic cerebral injury neurological function Sonic hedgehog transforming growth factorβ1 
The role of fibronectin in multiple sclerosis and the effect of drug delivery across the blood-brain barrier被引量：3
《Neural Regeneration Research》2023年第10期2147-2155,共9页Shuang-Shuang Wei Le Chen Feng-Yuan Yang Si-Qi Wang Peng Wang 
supported by the National Natural Science Foundation of China,Nos.82001282(to PW)and 81960232(to PW);Overseas Students’Innovation and Entrepreneurship Individual Project of Ningxia(2021)(to PW);Youth Talents Supporting Program of Ningxia Medical University and Ningxia,Nos.XT2019018(to PW),TJGC2019081(to PW);College Students’Innovation and En trepreneurship Training Program,No.X202210752038(to FYY)。
Remyelination failure is one of the main characteristics of multiple sclerosis and is potentially correlated with disease progression.Previous research has shown that the extracellular matrix is associated with remyel...
关键词：blood-brain barrier brain delivery EXOSOMES extracellular matrix fibronectin aggregates FIBRONECTIN intestinal flora multiple sclerosis remyelination failure REMYELINATION 
Neuron-fibrous scaffold interfaces in the peripheral nervous system: a perspective on the structural requirements被引量：1
《Neural Regeneration Research》2022年第9期1893-1897,共5页Sanaz Behtaj James A.St John Jenny A.K.Ekberg Maksym Rybachuk 
supported by a Garnett-Passe and Rodney Williams Memorial Foundation grant(to JE);a National Health and Medical Research Council grant,No.APP1183799(to JASJ and JAKE).
The nerves of the peripheral nervous system are not able to effectively regenerate in cases of severe neural injury.This can result in debilitating consequences,including morbidity and lifelong impairments affecting t...
关键词：electrospun scaffold extracellular matrix nerve conduit neural tissue engineering physical lumen filler scaffold topography structural support surface interaction 
Nerve bundle formation during the promotion of peripheral nerve regeneration:collagenⅥ-neural cell adhesion molecule 1 interaction被引量：2
《Neural Regeneration Research》2022年第5期1023-1033,共11页Jia-Hui Sun Ming Huang Zhou Fang Tian-Xiao Li Ting-Ting Wu Yi Chen Da-Ping Quan Ying-Ying Xu Yu-Ming Wang Yi Yang Jian-Long Zou 
supported by the National Natural Science Foundation of China,No.31800892(to JLZ);the Natural Science Foundation of Guangdong Province of China,No.2018A030310254(to YY);a grant from Guangzhou Medical University Start-up Project of China,No.B195002002048(to JLZ)。
The formation of nerve bundles,which is partially regulated by neural cell adhesion molecule 1(NCAM1),is important for neural network organization during peripheral nerve regeneration.However,little is known about how...
关键词：axonal fasciculation collagen VI extracellular matrix MICROENVIRONMENT nerve bundle formation nerve projection neural cell adhesion molecule 1 NEUROGENESIS peripheral nerve regeneration 
Lesion-induced changes of brevican expression in the perineuronal net of the superior vestibular nucleus
《Neural Regeneration Research》2022年第3期649-654,共6页Agnes Magyar Eva Racz Clara Matesz Ervin Wolf Peter Kiss Botond Gaal 
supported by the Hungarian Academy of Sciences–Office for Supported Research Groups:MTA-TKI 355;University of Debrecen–Medical and Health Sciences Center Bridging Fund;Hungarian Scientific Research Fund K115471.Obtained by Clara Matesz and colleagues。
Damage to the vestibular sense organs evokes static and dynamic deficits in the eye movements,posture and vegetative functions.After a shorter or longer period of time,the vestibular function is partially or completel...
关键词：BRAINSTEM BREVICAN chondroitin sulfate proteoglycan extracellular matrix labyrinth lesion neural plasticity perineuronal net perisynaptic matrix vestibular compensation vestibular system 
Protein post-translational modifications after spinal cord injury被引量：3
《Neural Regeneration Research》2021年第10期1935-1943,共9页Shuang Zhu Bing-Sheng Yang Si-Jing Li Ge Tong Jian-Ye Tan Guo-Feng Wu Lin Li Guo-Li Chen Qian Chen Li-Jun Lin 
This work was supported by the National Natural Science Foundation of China,No.81801210(to SZ).
Deficits in intrinsic neuronal capacities in the spinal cord,a lack of growth support,and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating consequences...
关键词：extracellular matrix function impairment glial scar nerve regeneration neuropathic pain post-translational modification spinal cord injury therapeutic target 
Cathepsins in neuronal plasticity
《Neural Regeneration Research》2021年第1期26-35,共10页Amanda Phuong Tran Jerry Silver 
JS was funded by NINDS(NS25713);Brumagin-Nelson Fund;Kaneko Family Fund;the Hong Kong Spinal Cord Injury Fund.
Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins,resulting in protein lysis.Cathepsins,specifically,encompass a class of at least twenty p...
关键词：axon regeneration CATHEPSIN CSPGs extracellular matrix growth cone LYSOSOMES neuronal plasticity PROTEASE remodeling spinal cord injury SYNAPTOGENESIS 
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