《Neural Regeneration Research》

作品数：7954被引量：18245H指数：33
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《Neural Regeneration Research》
主办单位：Chinese Association of Rehabilitation Medicine;Liaoning Society for Cell Biology
最新期次：2026年2期更多>>
发文主题：SPINAL_CORD_INJURYNEUROREGENERATIONNEUROPROTECTIONREGENERATIONGRANT更多>>
发文领域：医药卫生生物学农业科学文化科学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Metabolic reprogramming of astrocytes:Emerging roles of lactate
《Neural Regeneration Research》2026年第2期421-432,共12页Zeyu Liu Yijian Guo Ying Zhang Yulei Gao Bin Ning 
supported by the National Natural Science Foundation of China,Nos.82071383,82371392(to BN);the Natural Science Foundation of Shandong Province of China(Key Project),No.ZR2020KH007(to BN);“Taishan Scholar Distinguished Expert Program”of Shandong Province,No.tstp20231257(to BN);Health Commission Science and Technology Plan Project of Jinan,No.2023-1-8(to YZ).
Lactate serves as a key energy metabolite in the central nervous system,facilitating essential brain functions,including energy supply,signaling,and epigenetic modulation.Moreover,it links epigenetic modifications wit...
关键词：ASTROCYTE epigenetic modifications inflammation LACTATE lactylation METABOLIC PLASTICITY regeneration treatment 
Targeting the brain’s glymphatic pathway:A novel therapeutic approach for cerebral small vessel disease
《Neural Regeneration Research》2026年第2期433-442,共10页Yuhui Ma Yan Han 
supported by the National Natural Science Foundation of China,No.82274304(to YH);the Major Clinical Study Projects of Shanghai Shenkang Hospital Development Center,No.SHDC2020CR2046B(to YH);Shanghai Municipal Health Commission Talent Plan,No.2022LJ010(to YH).
Cerebral small vessel disease encompasses a group of neurological disorders characterized by injury to small blood vessels,often leading to stroke and dementia.Due to its diverse etiologies and complex pathological me...
关键词：AQUAPORIN-4 ASTROCYTES cerebral amyloid angiopathy cerebral small vessel disease cerebrospinal fluid diffusion tensor image analysis along the perivascular space glymphatic system interstitial fluid perivascular space therapeutic strategies 
Chemical exchange saturation transfer MRI for neurodegenerative diseases:An update on clinical and preclinical studies
《Neural Regeneration Research》2026年第2期553-568,共16页Ahelijiang Saiyisan Shihao Zeng Huabin Zhang Ziyan Wang Jiawen Wang Pei Cai Jianpan Huang 
supported by The University of Hong Kong,China(109000487,109001694,204610401,and 204610519);National Natural Science Foundation of China(82402225)(to JH).
Chemical exchange saturation transfer magnetic resonance imaging is an advanced imaging technique that enables the detection of compounds at low concentrations with high sensitivity and spatial resolution and has been...
关键词：Alzheimer’s disease chemical exchange saturation transfer Huntington’s disease magnetic resonance imaging molecular imaging multiple sclerosis neurodegenerative disease Parkinson’s disease 
Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease
《Neural Regeneration Research》2026年第2期569-576,共8页Qian Yue Shang Li Chon Lok Lei Huaibin Wan Zaijun Zhang Maggie Pui Man Hoi 
supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ);the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ;the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH);the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ);the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ).
Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More r...
关键词：Alzheimer’s disease brain microvessel endothelial cells transcriptomic heterogeneity endothelial activation blood-brain barrier impairment neurovascular cell-cell communication 
Recent advances in immunotherapy targeting amyloid-beta and tauopathies in Alzheimer’s disease
《Neural Regeneration Research》2026年第2期577-587,共11页Sha Sha Lina Ren Xiaona Xing Wanshu Guo Yan Wang Ying Li Yunpeng Cao Le Qu 
supported by the Nature Science Foundation of Liaoning Province,Nos.2022-MS-211,2021-MS-064,and 2024-MS-048(all to YC).
Alzheimer’s disease,a devastating neurodegenerative disorder,is characterized by progressive cognitive decline,primarily due to amyloid-beta protein deposition and tau protein phosphorylation.Effectively reducing the...
关键词：Alzheimer’s disease amyloid deposits AMYLOID-BETA antibody cognitive dysfunction dementia IMMUNOTHERAPY OLIGOMER preventive immunization tau hyperphosphorylation 
Stress granules:Guardians of cellular health and triggers of disease
《Neural Regeneration Research》2026年第2期588-597,共10页Meghal Desai Keya Gulati Manasi Agrawal Shruti Ghumra Pabitra KSahoo 
supported by a grant from the Merkin Peripheral Neuropathy and Nerve Regeneration Center(to PKS);the Rutgers University Startup Fund(to PKS).
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs(mRNAs)and regulating protein synthesis.Stress granules form...
关键词：apoptosis axon regeneration biomolecular condensates germline cell development mRNA transport NEURODEGENERATION NEURODEVELOPMENT PATHOPHYSIOLOGY physiological functions stress granules translation viral infection 
Role of mitophagy in spinal cord ischemia-reperfusion injury
《Neural Regeneration Research》2026年第2期598-611,共14页Yanni Duan Fengguang Yang Yibao Zhang Mingtao Zhang Yujun Shi Yun Lang Hongli Sun Xin Wang Hongyun Jin Xuewen Kang 
supported by Cuiying Scientific and Technological Innovation Program of Second Hospital of Lanzhou University,Nos.CY2023-QN-B18(to YD),2020QN-16(to YZ);the Natural Science Foundation of Gansu Province,No.22JR11RA082(to YZ);Key R&D Plan of Gansu Provincial Department of Science and Technology-Social Development Projects,No.23YFFA0043(to XK).
Spinal cord ischemia-reperfusion injury,a severe form of spinal cord damage,can lead to sensory and motor dysfunction.This injury often occurs after traumatic events,spinal cord surgeries,or thoracoabdominal aortic su...
关键词：BNIP3 BNIP3L/NIX FUNDC1 mechanism MITOCHONDRIA MITOPHAGY modulators PARKIN PINK1 spinal cord ischemia-reperfusion injury 
Neuronal guidance signaling in neurodegenerative diseases:Key regulators that function at neuron-glia and neuroimmune interfaces
《Neural Regeneration Research》2026年第2期612-635,共24页Junichi Yuasa-Kawada Mariko Kinoshita-Kawada Masaki Hiramoto Satoru Yamagishi Takayasu Mishima Shin’ichiro Yasunaga Yoshio Tsuboi Nobutaka Hattori Jane Y.Wu 
supported by JSPS(KAKENHI:21K06205,23K06937,24K23419);AMED(to JYK,SaY,TM,SiY,YT,and NH);JYW had long been supported by the NIH.
The nervous system processes a vast amount of information,performing computations that underlie perception,cognition,and behavior.During development,neuronal guidance genes,which encode extracellular cues,their recept...
关键词：amyloid-β axon guidance NEURODEGENERATION neuroimmune interactions neuroinflammation neuron-glia interactions neurovascular interactions SEMAPHORIN synaptic remodeling tau TDP-43 TREM2 Α-SYNUCLEIN 
Novel insights into non-coding RNAs and their role in hydrocephalus
《Neural Regeneration Research》2026年第2期636-647,共12页Zhiyue Cui Jian He An Li Junqiang Wang Yijian Yang Kaiyue Wang Zhikun Liu Qian Ouyang Zhangjie Su Pingsheng Hu Gelei Xiao 
supported by the National Natural Science Foundation of China,Nos.82171347,82371362;the Natural Science Foundation of Hunan Province,No.2022JJ30971;the Scientific Research Project of Hunan Provincial Health Commission of China,No.202204040024(all to GX).
A large body of evidence has highlighted the role of non-coding RNAs in neurodevelopment and neuroinflammation.This evidence has led to increasing speculation that non-coding RNAs may be involved in the pathophysiolog...
关键词：HYDROCEPHALUS NEURODEVELOPMENT NEUROINFLAMMATION non-coding RNA therapeutic target 
Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?
《Neural Regeneration Research》2026年第2期648-658,共11页Shuangchan Wu Jun Chen 
supported by grants from Guangdong Basic and Applied Basic Research Foundation,No.2021A1515110801(to SW);the National Natural Science Foundation of China,No.82301511(to SW);“Double First-Class”Construction Project of NPU,Nos.0515023GH0202320(to JC),0515023SH0201320(to JC)and 973 Program,No.2011CB504100(to JC).
Myelination,the continuous ensheathment of neuronal axons,is a lifelong process in the nervous system that is essential for the precise,temporospatial conduction of action potentials between neurons.Myelin also provid...
关键词：aging Alzheimer’s disease multiple sclerosis MYELIN myelin-axon metabolite crosstalk myelinodegeneration neurodegenerative disease OLIGODENDROCYTE Parkinson’s disease white matter 
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