METABOLISM

作品数:1864被引量:5736H指数:32
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相关领域:医药卫生更多>>
相关作者:钟大放钱之玉王广基柳晓泉李燕更多>>
相关机构:沈阳药科大学中国科学院浙江大学清华大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>
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  • 期刊=Neural Regeneration Researchx
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Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity
《Neural Regeneration Research》2025年第9期2577-2578,共2页Jiazi Tan Chin-Tong Ong 
supported by core funding provided by Temasek Life Sciences Laboratory(to CTO)。
Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE pr...
关键词:METABOLISM GLYCOPROTEIN MAINTAIN 
Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy
《Neural Regeneration Research》2025年第8期2264-2278,共15页You Wu Lijie Yang Wanrong Jiang Xinyuan Zhang Zhaohui Yao 
supported by the National Natural Science Foundation of China,No.82271214(to ZY);the Natural Science Foundation of Hubei Province of China,No.2022CFB109(to ZY)。
Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments.The current therapeutic strategies,primarily based on cholinest...
关键词:Alzheimer’s disease glial cells GLYCOLYSIS neuronal metabolism PATHOGENESIS therapeutic targets 
Cryptic exon inclusion in TDP-43 proteinopathies:opportunities and challenges
《Neural Regeneration Research》2025年第7期2003-2004,共2页Lorena Decker Sonja Menge Axel Freischmidt 
supported by the Deutsche Forschungsgemeinschaft(DFG;grant#521487152)(to AF)。
TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcr...
关键词:HUNTINGTON METABOLISM TDP 
Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies
《Neural Regeneration Research》2025年第3期803-804,共2页Glenn A.Harris Lauren R.Hirschfeld 
supported by the Rainwater Charitable Foundation。
Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as eit...
关键词:TAU METABOLISM DISEASES 
Corrigendum: Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism
《Neural Regeneration Research》2025年第2期401-401,共1页
In the article titled“Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism,”published on pages 650-656,Issue 3,Volum...
关键词:METABOLISM ENDOTHELIN 
Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism
《Neural Regeneration Research》2025年第1期41-53,共13页Alessio Canovai Pete A.Williams 
supported by Karolinska Institutet in the form of a Board of Research Faculty Funded Career Position;by St.Erik Eye Hospital philanthropic donations;Vetenskapsrådet 2022-00799.
Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/tissues.Pyrroloquinoline quinone is present in the di...
关键词:METABOLISM MITOCHONDRIA neurodegenerative disease NEUROPROTECTION pyrroloquinoline quinone retinal diseases 
Oligodendroctyes:the forgotten players of diabetes pathophysiology
《Neural Regeneration Research》2024年第11期2349-2350,共2页Juan Antonio López-Villodres Beatriz García-Díaz 
funded by Instituto de Salud Carlos Ⅲ(ISCⅢ)through the project“CP20-0049”;co-funded by the European Union(to BGD).
Oligodendrocytes(OLs),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual role.First,this myelin fatty cover around the axons protects the nerves and is crucial for the salt...
关键词:METABOLISM NERVES MYELIN 
Actin(g) toward a revised understanding of the role of cytoskeletal dynamics in neuronal bioenergetics
《Neural Regeneration Research》2024年第10期2109-2110,共2页Sabrina M.Holland Gianluca Gallo 
supported by National Institute of Health awards NS118000 and NS128049 (to GG)。
Neurons are energy-demanding cells.Disruptions in energy metabolism can quickly interrupt neuronal function,leading to cell death and neurodegeneration.For instance,ischemia rapidly depletes adenosine triphosphate(ATP...
关键词:METABOLISM HOMEOSTASIS DEGENERATION 
Metabolic reprogramming of the inflammatory response in the nervous system:the crossover between inflammation and metabolism
《Neural Regeneration Research》2024年第10期2189-2201,共13页Jesus Amo-Aparicio Charles A.Dinarello Ruben Lopez-Vales 
supported by NIH Grant Al-15614 (to CAD);the Ministerio de Ciencia e Innovacion (PID2020-120267BRI00AEI/10.13039/501100011033)(to RLV)。
Metabolism is a fundamental process by which biochemicals are broken down to produce energy(catabolism) or used to build macromolecules(anabolism). Metabolism has received renewed attention as a mechanism that generat...
关键词:central nervous system fatty acid oxidation GLYCOLYSIS INFLAMMATION macrophage METABOLISM microglia NEURODEGENERATION oxidative phosphorylation 
Application of artificial hibernation technology in acute brain injury被引量:2
《Neural Regeneration Research》2024年第9期1940-1946,共7页Xiaoni Wang Shulian Chen Xiaoyu Wang Zhen Song Ziqi Wang Xiaofei Niu Xiaochu Chen Xuyi Chen 
supported by the National Defense Science and Technology Outstanding Youth Science Fund Project,No.2021-JCJQ-ZQ-035;National Defense Innovation Special Zone Project,No.21-163-12-ZT-006-002-13;Key Program of the National Natural Science Foundation of China,No.11932013(all to XuC).
Controlling intracranial pressure,nerve cell regeneration,and microenvironment regulation are the key issues in reducing mortality and disability in acute brain injury.There is currently a lack of effective treatment ...
关键词:cute brain injury artificial hibernation HYPOTHERMIA low metabolism mild hypothermia 
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