云南高校图书馆联盟文献共享服务平台- MICROTUBULES

MICROTUBULES: 作品数：127被引量：213H指数：8; 导出分析报告; 相关领域：生物学更多>>; 相关作者：徐是雄叶秀麟梁承邺李素丽杨丽涛更多>>; 相关机构：香港大学中国科学院广西大学广西农业科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金中国科学院科研项目更多>>

Towards mechanism-based tau-targeted therapies: 《Neural Regeneration Research》2026年第2期687-688,共2页Lidia Bakota Roland Brandt; Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta...; 关键词：tau targeted therapies cellular components mechanism based therapies cellular componentswhich cellular models MICROTUBULES TAUOPATHIES neurodegenerative diseasescollectively

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice: 《Neural Regeneration Research》2025年第8期2348-2360,共13页Mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel; supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne,the Alzheimer Forschung Initiative e.V.(grant#22039,to HZ);open-access funding from the DFG/GRC issued to the University of Cologne;Alzheimer Forschung Initiative e.V.for Open Access Publishing(a publication grant#P2401,to MAAK)。; TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon.TAU is missorted and aggregated in an array of diseases known as tauopathies.Microtubules are essential for neuronal...; 关键词：human induced pluripotent stem cell MICROTUBULES P301L pR5 mice TAU TAUOPATHY tubulin code

How do neurons age?A focused review on the aging of the microtubular cytoskeleton被引量：1: 《Neural Regeneration Research》2024年第9期1899-1907,共9页Brad Richardson Thomas Goedert Shmma Quraishe Katrin Deinhardt Amritpal Mudher; funded by the Gerald Kerkut Charitable Trust (GKT)(to BR); Aging is the leading risk factor for Alzheimer’s disease and other neurodegenerative diseases. We now understand that a breakdown in the neuronal cytoskeleton, mainly underpinned by protein modifications leading to t...; 关键词：age-related changes AGING CYTOSKELETON MICROTUBULES neuronal morphology

Connecting neurodevelopment to neurodegeneration:a spotlight on the role of kinesin superfamily protein 2A(KIF2A)被引量：1: 《Neural Regeneration Research》2024年第2期375-379,共5页Nuria Ruiz-Reig Janne Hakanen Fadel Tissir; Fund for Scientific Research(FNRS)PDR T0236.20;FNRS-Exellence of Science 30913351;FNRS CDR J.0175.23(to FT)。; Microtubules play a central role in cytoskeletal changes during neuronal development and maintenance.Microtubule dynamics is essential to polarity and shape transitions underlying neural cell division,differentiation,...; 关键词：brain disorders cortical malformations KINESIN MICROTUBULES NEURODEGENERATION NEURODEVELOPMENT

Fidgetin interacting with microtubule end binding protein EB3 affects axonal regrowth in spinal cord injury被引量：1: 《Neural Regeneration Research》2023年第12期2727-2732,共6页Chao Ma Junpei Wang Qifeng Tu Weijuan Bo Zunlu Hu Run Zhuo Ronghua Wu Zhangji Dong Liang Qiang Yan Liu Mei Liu; the National Natural Science Foundation of China,Nos.32070725(to ML),82001295(to RHW),31970412(to YL);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions。; Fidgetin,a microtubule-severing enzyme,regulates neurite outgrowth,axonal regeneration,and cell migration by trimming off the labile domain of microtubule polymers.Because maintenance of the microtubule labile domain ...; 关键词：acetylated microtubules axon regeneration axonal branching axonal regrowth end binding protein 3 fidgetin microtubule dynamics sciatic nerve injury spinal cord injury tyrosinated microtubules

Modeling protein-protein interactions in axon initial segment to understand their potential impact on action potential initiation: 《Neural Regeneration Research》2021年第4期700-706,共7页Piyush Bhardwaj Don Kulasiri Sandhya Samarasinghe; The axon initial segment(AIS)region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels(Nav).Nav channels comprise several serine residues responsib...; 关键词：Alzheimer’s disease ANKYRIN-G axon initial segment casein kinase-2 MICROTUBULES voltage-gated potassium channel voltage-gated sodium channel

Tubulin glutamylation: a skeleton key for neurodegenerative diseases被引量：1: 《Neural Regeneration Research》2019年第11期1899-1900,共2页Siem van der Laan Geronimo Dubra Krzysztof Rogowski; supported by ANR-13-JSV2-0002,Centre d’Excellence en maladies Neuro-dégénératives(CoEN)de Montpellier and France Alzheimer; Microtubules (MTs) are cytoskeletal elements formed by a non-covalent association of α- and β-tubulin heterodimers. They provide structure and shape to all eukaryotic cells and are implicated in a variety of fundame...; 关键词：NEURODEGENERATIVE DISEASES Microtubules(MTs) cellular processes

Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer＇s disease被引量：2: 《Neural Regeneration Research》2018年第6期1066-1080,共15页Sara H.Mokhtar Min Joung Kim Kylie A.Magee Pei Mun Aui Speros Thomas Maha M.Bakhuraysah Amani A.Alrehaili Jae Young Lee David L.Steer Rachel Kenny Catriona Mc Lean Michael F.Azari Antonis Birpanagos Ewlina Lipiec Philip Heraud Bayden Wood Steven Petratos; supported by King Abdul-Aziz University postgraduate scholarship(to SHM);the National Multiple Sclerosis Society(USA)Project Grant ID#RG43981/1(to SP); Alzheimer’s disease（AD）is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles.Prior to the development of these characteristic pathological hallmarks of AD,ante...; 关键词：amyloid-beta protein kinases collapsin response mediator protein MICROTUBULES KINESIN TUBULIN

Formin' bridges between microtubules and actin filaments in axonal growth cones: 《Neural Regeneration Research》2017年第12期1971-1973,共3页István Foldi Szilárd Szikora József Mihály; supported by the Hungarian Science Foundation(OTKA)(K109330 to JM);the Hungarian Brain Research Program(KTIA_NAP_13-2-2014-0007 to JM);the National Research,Development and Innovation Office(GINOP-2.3.2-15-2016-00001 and GINOP-2.3.2-15-2016-00032 to JM);by an MTA Postdoctoral Fellowship(to IF); It is well established that guidance of axons during neuronal development is regulated by a variety of extracellular signals,governing cytoskeletal dynamics in growth cones.The actin and microtubule（MT）cytoskeleton ...; 关键词：Formin＇＇ bridges axonal growth cones

Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system被引量：2: 《Neural Regeneration Research》2017年第8期1231-1240,共10页Julia J.Segura-Uribe Rodolfo Pinto-Almazán Angélica Coyoy-Salgado Claudia E.Fuentes-Venado Christian Guerra-Araiza; supported by FIS/IMSS project No.FIS/IMSS/PROT/G13/1216;CGA received Beca de Excelencia en Investigación by Fundación IMSS,ACS;JJSU received financial support from CIS/IMSS;CONACy T,RPA received financial support from USC-CONACYT Postdoctoral Scholars Program; Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer...; 关键词：estrogen receptor modulators selective estrogen receptor modulators MICROTUBULES NEUROFILAMENTS TIBOLONE TAMOXIFEN RALOXIFENE

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