PROTEIN

作品数：2328被引量：5787H指数：25
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ABCA5 lipid transporter is associated with a reduced risk of Parkinson’s disease
《Neural Regeneration Research》2026年第2期669-670,共2页Jasmin Galper Nicolas Dzamko Woojin Scott Kim 
A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative...
关键词：neurodegenerative diseases lipid transporter abca LYSOSOME protein build up Alzheimers disease cellular materials Parkinsons disease 
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons被引量：15
《Neural Regeneration Research》2023年第2期357-363,共7页Wei-Tao Yan Wen-Juan Zhao Xi-Min Hu Xiao-Xia Ban Wen-Ya Ning Hao Wan Qi Zhang Kun Xiong 
supported by the National Natural Science Foundation of China,Nos.81772134,81971891,82172196,81571939(ail to KX);the Key Laboratory of Emergency and Trauma(Hainan Medical University)of Ministry of Education,No.KLET-202108(to KX);the Fundamental Research Funds for the Central Universities of Central South University of China,No.2020zzts218(to WTY);Hunan Provincial Innovation Foundation for Postgraduate of China,No.CX20200116(to WTY)。
PANoptosis is a newly identified type of regulated cell death that consists of pyroptosis,apoptosis,and nec roptosis,which simultaneously occur during the pathophysiological process of infectious and inflammatory dise...
关键词：apoptosis gasdermin-D(GSDMD) ISCHEMIA/REPERFUSION mixed lineage kinase domain-like protein(MLKL) NECROPTOSIS NOD-like receptor protein 3(NLRP3) PANoptosis PYROPTOSIS receptor-interacting protein kinase 3(RIPK3) retinal neuron 
Gene and protein expression profiles of olfactory ensheathing cells from olfactory bulb versus olfactory mucosa被引量：1
《Neural Regeneration Research》2022年第2期440-449,共10页Yuan-Xiang Lan Ping Yang Zhong Zeng Neeraj Yadav Li-Jian Zhang Li-Bin Wang He-Chun Xia 
supported by Key Research Projects of Ningxia Hui Autonomous Region of China,No.2018BCG01002(to HCX);the Natural Science Foundation of Ningxia Hui Autonomous Region of China,No.NZ17150(to PY)。
Olfactory ensheathing cells(OECs) from the olfactory bulb(OB) and the olfactory mucosa(OM) have the capacity to repair nerve injury. However, the difference in the therapeutic effect between OB-derived OECs and OM-der...
关键词：biological process cellular component GENE Gene Ontology Kyoto Encyclopedia of Genes and Genomes molecular function olfactory bulb olfactory ensheathing cells olfactory mucosa PROTEIN 
Protein post-translational modifications after spinal cord injury被引量：3
《Neural Regeneration Research》2021年第10期1935-1943,共9页Shuang Zhu Bing-Sheng Yang Si-Jing Li Ge Tong Jian-Ye Tan Guo-Feng Wu Lin Li Guo-Li Chen Qian Chen Li-Jun Lin 
This work was supported by the National Natural Science Foundation of China,No.81801210(to SZ).
Deficits in intrinsic neuronal capacities in the spinal cord,a lack of growth support,and suppression of axonal outgrowth by inhibitory molecules mean that spinal cord injury almost always has devastating consequences...
关键词：extracellular matrix function impairment glial scar nerve regeneration neuropathic pain post-translational modification spinal cord injury therapeutic target 
Clusterin: a multifaceted protein in the brain被引量：2
《Neural Regeneration Research》2021年第7期1438-1439,共2页Hee-Jung Moon Sarah K.Herring Liqin Zhao 
supported by the National Institutes of Health(NIH;R21 AG055964, R21 AG059177, R01 AG061038 to LZ)。
Late-onset Alzheimer 's disease(LOAD), the most common cause of dementia, currently affects 5.6 million Americans ages 65 and older.LOAD is a neurodegenerative disorder characterized by progressive loss in synaptic fu...
关键词：CLUSTERIN ALZHEIMER ATROPHY 
Navigating the dynamic landscape of alpha-synuclein morphology: a review of the physiologically relevant tetrameric conformation被引量：1
《Neural Regeneration Research》2020年第3期407-415,共9页Heather R.Lucas Ricardo D.Fernández 
supported in part by Award No.18-7(to HRL)from the Commonwealth of Virginia’s Alzheimer’s and Related Diseases Research Award Fund,administered by the Virginia Center on Aging
N-acetylatedα-synuclein(αSyn)has long been established as an intrinsically disordered protein associated with a dysfunctional role in Parkinson’s disease.In recent years,a physiologically relevant,higher order conf...
关键词：ALPHA-SYNUCLEIN amyloid FIBRILS intrinsically disordered PROTEIN MULTIMER N-ACETYLATION oligomer Parkinson’s disease PROTEIN folding PROTEIN structure TETRAMER 
Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain?被引量：1
《Neural Regeneration Research》2019年第7期1148-1151,共4页Zhefan Stephen Chen Ho Yin Edwin Chan 
supported by the General Research Fund(14100714)of the Hong Kong Research Grants Council(to HYEC);The Chinese University of Hong Kong Vice-Chancellor’s One-Off Discretionary Fund(VCF2014011)(to HYEC);The Chinese University of Hong Kong One-of Funding for Joint Lab/Research Collaboration(3132980)(to HYEC);The Chinese University of Hong Kong Faculty of Science Strategic Development Fund(FACULTY-P17173)(to HYEC);The Chinese University of Hong Kong Gerald Choa Neuroscience Centre(7105306)(to HYEC);donations from Chow Tai Fook Charity Foundation(6903898)(to HYEC);Hong Kong Spinocerebellar Ataxia Association(6903291)(to HYEC);supported by the Postdoctoral Fellowship in Clinical Neurosciences of The Chinese University of Hong Kong,China
Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration...
关键词：Alzheimer’s disease amyotrophic lateral SCLEROSIS neurodegeneration PROTEIN aggregates recruitment PROTEIN degradation SUBCELLULAR localization TRANSCRIPTIONAL regulation YIN Yang 1 
Vacuolar protein sorting protein 41(VPS41) at an intersection of endosomal traffic in neurodegenerative disease
《Neural Regeneration Research》2019年第7期1210-1212,共3页Edward F.Griffin Kim A.Caldwell Guy A.Caldwell 
Alzheimer’s and Parkinson’s diseases are neurodegenerative disorders pathologically classified by the accumulation of amyloidogenic proteins into insoluble inclusions within the brain.Specifically,amyloid plaques in...
关键词：commissural AXON GUIDANCE pathologically 
GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury被引量：17
《Neural Regeneration Research》2019年第7期1221-1229,共9页Zi-Wei Han Yue-Chen Chang Ying Zhou Hang Zhang Long Chen Yang Zhang Jun-Qiang Si Li Li 
supported by the National Natural Science Foundation of China,No.81560175,81260159(both to LL)
Studies have confirmed a strong association between activation of the endoplasmic reticulum stress pathway and cerebral ischemia/reperfusion(I/R) injury.In this study,three key proteins in the endoplasmic reticulum st...
关键词：nerve REGENERATION cerebral ischemia/reperfusion injury ESTROGEN G protein-coupled ESTROGEN receptor G1 G15 endoplasmic reticulum stress glucose-regulated PROTEIN 78 caspase-12 C/EBP homologous PROTEIN neuronal apoptosis neural REGENERATION 
The paradigm of protein acetylation in Parkinson's disease被引量：2
《Neural Regeneration Research》2019年第6期975-976,共2页Sokhna M.S.Yakhine-Diop Guadalupe Martínez-Chacón Elisabet Uribe-Carretero Mireia Niso-Santano Rosa A.González-Polo José M.Fuentes 
Acetylation is a post-translational modification that is regulated by two antagonistic enzymes,histone acetyltransferases(HATs)and histone deacetylases(HDACs).HATs transfer the acetyl group from acetyl-CoA to lysine r...
关键词：PARKINSON PROTEIN Α-SYNUCLEIN HDACS cells GENE is 
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