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ROLES: 作品数：1132被引量：4011H指数：26; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：陈慧王伊林王书奎文岳中刘维屏更多>>; 相关机构：浙江大学浙江师范大学中南大学北京师范大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>

Roles of alternative splicing in infectious diseases: from hosts, pathogens to their interactions被引量：1: 《Chinese Medical Journal》2023年第7期767-779,共13页Mengyuan Lyu Hongli Lai Yili Wang Yanbing Zhou Yi Chen Dongsheng Wu Jie Chen Binwu Ying; National Natural Science Foundation of China(No.82272416); Alternative splicing(AS)is an evolutionarily conserved mechanism that removes introns and ligates exons to generate mature messenger RNAs(mRNAs),extremely improving the richness of transcriptome and proteome.Both mamm...; 关键词：Alternative splicing Infectious diseases SPLICEOSOME Regulation mechanism Targeted drug

Molecular mechanisms and roles of pyroptosis in acute lung injury被引量：6: 《Chinese Medical Journal》2022年第20期2417-2426,共10页Tianchang Wei Cuiping Zhang Yuanlin Song; Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),which are characterized by excessive inflammation and accompanied by diffuse injury of alveoli,can result in severe respiratory failures.The morbidit...; 关键词：Acute lung injury Acute respiratory distress syndrome CASPASE Coronavirus disease 2019(COVID-19) Gasdermin INFLAMMASOME PYROPTOSIS

Ferroptosis and its emerging roles in acute pancreatitis被引量：8: 《Chinese Medical Journal》2022年第17期2026-2034,共9页Hongyao Li Yujie Lin Ling Zhang Jing Zhao Peiwu Li; This study was supported by a grant from the Lanzhou Talent Innovation and Entrepreneurship Project(No.2016-RC-52).; Acute pancreatitis(AP)is a common and potentially life-threatening pancreatic inflammatory disease.Although it is usually self-limiting,up to 20%of patients will develop into severe AP.It may lead to systemic inflamma...; 关键词：Acute pancreatitis Ferroptosis RCD AUTOPHAGY GPX4 PUFAS Regulated cell death

Roles of organelle-specific autophagy in hepatocytes in the development and treatment of non-alcoholic fatty liver disease被引量：1: 《Chinese Medical Journal》2022年第14期1673-1681,共9页Yizhi Zhang Yu Chen; supported by grants from the Beijing Advanced Innovation Center for Big Data-Based Precision Medicine(No.PXM2021_014226_000026);the Capital Funds for Health Improvement and Research(No.2021-1G-2181).; Non-alcoholic fatty liver disease(NAFLD)is a disorder of lipid metabolism.The lipotoxic intermediates of lipid metabolism cause mitochondrial dysfunction and endoplasmic reticulum stress.Organelle-specific autophagy i...; 关键词：AUTOPHAGY Lipophagy MITOPHAGY Reticulophagy Non-alcoholic fatty liver disease

Roles of adenosine monophosphate-activated protein kinase(AMPK)in the kidney被引量：1: 《Chinese Medical Journal》2022年第4期488-490,共3页Na Zhu Min Han; To the Editor:The kidney is a highly energy-consuming organ and is prone to damage if there is an energy supply disorder.Adenosine monophosphate(AMP)-activated protein kinase(AMPK)is a serine/threonine kinase that pla...; 关键词：KIDNEY METABOLISM HOMEOSTASIS

Roles of AKR1C3 in malignancy被引量：2: 《Chinese Medical Journal》2021年第9期1052-1054,共3页Xin-Zhu Xiao Li-Ying Lin Ming-Kai Zhuang Can-Mei Zhong Feng-Lin Chen; supported by the Medical Innovation Project of Fujian Province(No.2019-CX-14);the Joint Funds for the Innovation of Science and Technology,Fujian province(No.2019Y9083);the Fujian Medical University Cancer Center and the Key Clinical Specialty Discipline Construction Program of Fujian,China(No.Min Wei Ke Jiao 2012 No.149)。; The superfamily of aldo-keto reductases(AKRs)is composed of over 190 members and can be classified into 16 different families(visit www.med.upenn.edu/akr).AKR1C3(C3 subtype of aldosterone reductase family 1)refers to ...; 关键词：DINUCLEOTIDE AKR1C3 ADENINE

Insight into the roles of long non-coding RNAs in ultraviolet-induced skin diseases: 《Chinese Medical Journal》2021年第4期398-400,共3页Yu-Jia Wang Xian Jiang; This research was supported by a grant from the National Natural Science Foundation of China(No.81872535)。; Long non-coding RNAs(LncRNAs)comprise different types of RNA polymerase II-transcripted molecules,exhibit nucleotide lengths of greater than 200 nucleotides and do not undergo protein translation.Due to their characte...; 关键词：DISEASES ULTRAVIOLET RNAS

Roles of short-chain fatty acids in kidney diseases被引量：12: 《Chinese Medical Journal》2019年第10期1228-1232,共5页Ling-Zhi Li Si-Bei Tao Liang Ma Ping Fu; Objective: In kidney diseases, uncontrolled blood pressure, inflammation, oxidative stress, imbalanced immunity response, metabolic dysfunction were associated with the progressive deterioration of renal function. Sho...; 关键词：GUT MICROBIOME Short-chain FATTY acid KIDNEY disease Gut-kidney AXIS

Roles of Loss of Chromosome 14q Allele in the Prognosis of Renal Cell Carcinoma with C-reactive Protein Abnormity被引量：2: 《Chinese Medical Journal》2017年第18期2176-2182,共7页Gang Wang Da-Ming Zhang Hai-Ying Zhuang Chao Yin Jing Liu Zi-Chun Wang Li-Cheng Cai Ming-Hua Ren Wan-Hai Xu Cheng Zhang; This work was supported by grants from the National Natural Science Foundations of China （No. 81171996, and No. 81272289）.; Background：Renal cell carcinoma （RCC） is frequently associated with paraneoplastic inflammatory syndrome （PIS）.This study aimed at exploring the connections between the survival rate and specific gene alterations...; 关键词：C-reactive Protein Gene Alterations Loss of Chromosome Paraneoplastic Inflammatory Syndrome Renal Cell Carcinoma

Roles of preoperative arterial blood gas tests in the surgical treatment of scoliosis with moderate or severe pulmonary dysfunction被引量：1: 《Chinese Medical Journal》2012年第2期249-252,共4页Liu Jia-ming Shen Jian-xiong Zhang Jian-guo Zhao Hong Li Shu-gang Zhao Yu Qu Giu-xing; Background It has been stated that preoperative pulmonary function tests are essential to assess the surgical risk in patients with scoliosis.Arterial blood gas tests have also been used to evaluate pulmonary function...; 关键词：SCOLIOSIS pulmonary dysfunction blood gas analysis COMPLICATIONS

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