GENE_TRANSFER

作品数：204被引量：510H指数：11
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相关机构：武汉大学中国医学科学院阜外心血管医院大连民族大学青岛大学医学院附属医院更多>>
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Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma被引量：13
《中国实验血液学杂志》1997年第3期301-302,共2页Miguel Idoate Roberto Bilbao Bruno Sangro Oscar Bruna Jesus Vazquez Jesus Prieto 
Viral-mediated gene transfer of thymidine kinase ofherpes simplex virus (HSV-tk) has been used to confercytotoxic sensitivity to ganciclovir (GCV) in a variety oftnmor cells. HSV-tk converts GCV into a phosphorylatedc...
关键词：THYMIDINE simplex nodules cytotoxic ADENOVIRUS NUDE dividing inhibit ORTHOTOPIC affects 
Human interleukin-2 gene transfer into ovarian cancer cell lines SKOV3, decreased the proliferation, tumorigenesis and enhanced the immunity of the tumor cells
《中国实验血液学杂志》1997年第3期308-308,共1页Zhen-Yu Zhang, Ning Guo, Jing-He Lang, Ning Mao,Pei-Hsien TangBeijing Institute of Basic Medical Sciences, Beijing100850 
To study the effects of human interleukin-2 genetransfer on the morphology, proliferation, tumori-genesis, immunity, and oncogenes expression of tumorcells, the gene encoding human interleukin-2 (IL-2) wasintroduced v...
关键词：interleukin IMMUNITY TUMORIGENESIS encoding clone morphologic PARENTAL collagen vaccine lymphocyte 
Effective cellular vaccines generated by in vitro or in vivo modification of tumor cells using gene transfer approaches for cancer immunogene therapy
《中国实验血液学杂志》1997年第3期284-285,共2页Y.J.Guo F.Shen T.P.Xie X.Che Z.F.Cui L.Shi J.Ma S.G.Wu X.N.Wang G.L.Liu Y.Liu H.Wang H.L.Huang L.X.Wei J.Zhao J.Trojan A.Ly D.Anthony M.C.Wu 
Tumor cells escape host immune surveillance bydown-regulation of MHC and/or co-stimulatorymolecules.Anti-tumor immune responses are mediated primarily by T cells.A deficiency in either MHC or co-stimulatory molecules ...
关键词：vaccines surveillance immunity TRANSFECTION recurrence MANNER ESCAPE CURATIVE elicit inducing 
Retroviral mediated human β-globin gene transfer and expression in vitro
《中国实验血液学杂志》1997年第3期286-286,共1页Depei Liu, Chih-Chuan Liang National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005 
Retroviral mediated gene transfer of humanglobin gene into hematopoietic stem cells is apromising approach for thalassemia gene therapy.Major problem of the transferred globin gene was lowlevel expression of the gene ...
关键词：GLOBIN HEMATOPOIETIC proximal HYPERSENSITIVE locus enhancer packaging Major transferred induction 
Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer被引量：2
《中国实验血液学杂志》1997年第3期322-322,共1页Jennifer L.Horton Elena B.Samoilova Thomas A.Judge Laurence A.Turka James M.Wilson 
Both rheumatoid arthritis and animal models ofautoimmune arthritis are characterized by hyper-activation of synovial cells and hyperplasia of the synovialmembrane. The activated synovial cells produceinflammatory cyto...
关键词：collagen CARTILAGE DESTRUCTION cytokines bones elimination enzymes AUTOIMMUNE inflammation unlike 
Effects on proliferative activity of 1L-2 gene modified K562 cells by retroviral mediated gene transfer被引量：1
《中国实验血液学杂志》1997年第3期324-324,共1页N.Guo, X.S.Li, X.D.Liu, Y.Yang, N.Mao, P. H.TangBeijing Institute of Basic Medical Sciences, Beijing100850 
In the present study, human IL-2 gene wastransferred into human erythroleukemic cell line K562 bythe retroviral vector LYCN. The effects on theproliferative activity of the IL-2-gene-modified K562 cells（K562/IL2） we...
关键词：PROLIFERATIVE CYTOMETRY portion accumulated CYTOPLASMIC markedly TRANSDUCTION morphological ladder remarkable 
Experimental studies on gene transfer into hematopoietic stem cells mediated by liposome and the influence of expansion on gene expression
《中国实验血液学杂志》1997年第3期326-326,共1页Hua-Zhong Lu, Ping Zou, Chong-Yu Li, Zhi-Fu Xiang Hematology Institute, Tongji Medical University, Wuhan430022 
Liposomes have several advantages over viral vectorsfor gene delivery both in vitro and in vivo. However,few data are available concerning gene transfer intohematopoietic stem cells. In order to explore theefficiency ...
关键词：HEMATOPOIETIC LIPOSOME concerning COLONY expanded MARKER remarkably stain 
Therapeutic effects of combined suicide gene and granulocyte-macrophage colony stimulating factor gene transfer on erythroleukemia in mice
《中国实验血液学杂志》1997年第3期327-327,共1页Baomei Wang, Dianwen Ju, Qun Tao, Yizhi Yu, Xuetao CaoDepartment of Immunology, The Second Military MedicalUniversity, Shanghai 200433 
Adenoviruses harboring E. coli. cytosine deaminase(CD) gene (Ad-CD) and murine granulocyte-macrophage colony stimulating factor (GM-CSF) gene(Ad-GM-CSF) were used for gene transfer in vivo.(C57BL/6 mice were inoculate...
关键词：GRANULOCYTE macrophage COLONY DEAMINASE stimulating CYTOSINE inoculated immunity inoculation murine 
Skeletal myoblast-mediated gene transfer for hemophilia B gene therapy
《中国实验血液学杂志》1997年第3期328-328,共1页K.Kurachi 
Myoblast-mediated gene transfer approach has agreat potential to be developed into a durable genetherapy method for various diseases. To increase theexpression level of human factor Ⅸ (hFⅨ) in musclecells, we constr...
关键词：SKELETAL INTRON promoter maintained battery INJECTIONS persistent SCID implanted stably 
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