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SYNAPTIC: 作品数：319被引量：717H指数：13; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：于洋余剑平赵志奇熊志奇杨柳更多>>; 相关机构：中国科学院加拿大多伦多大学第四军医大学滨州医学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家教育部博士点基金更多>>

Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching: 《Neural Regeneration Research》2025年第9期2624-2632,共9页Jangampalli Adi Pradeepkiran Priyanka Rawat Arubala P.Reddy Erika Orlov PHemachandra Reddy; supported by NIH grants AG079264(to PHR)and AG071560(to APR)。; The process of neurite outgrowth and branching is a crucial aspect of neuronal development and regeneration.Axons and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are use...; 关键词：diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly: 《Neural Regeneration Research》2025年第5期1409-1410,共2页Rafael Lujan Alejandro Martín-Belmonte Sergi Ferré Francisco Ciruela; Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic plasticity.AD has progressively been recognized as syna ptopathy and ...; 关键词：ALZHEIMER PATHOLOGY

The role of axon guidance molecules in the pathogenesis of epilepsy: 《Neural Regeneration Research》2025年第5期1244-1257,共14页Zheng Liu Chunhua Pan Hao Huang; supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。; Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target no...; 关键词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation: 《Neural Regeneration Research》2025年第2期326-342,共17页Yi Ji Chaoyi Yang Xuerui Pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang; supported by the Hefei Comprehensive National Science Center Hefei Brain Project(to KW);the National Natural Science Foundation of China,Nos.31970979(to KW),82101498(to XW);the STI2030-Major Projects,No.2021ZD0201800(to PH).; Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neur...; 关键词：Alzheimer’s disease amyloid deposition apoptotic mechanisms BIOMARKER neural regeneration NEURODEGENERATION repetitive transcranial magnetic stimulation synaptic plasticity

Apoer2/Lrp8:the undercover cop of synaptic homeostasis: 《Neural Regeneration Research》2024年第12期2563-2564,共2页Gordon C.Werthmann Joachim Herz; supported by NIH grants NS093382,NS108115,AG053391,HL063762 (to JH);supported by Blue Field Project to Cure FTD,BrightFocus Foundation (A20135245 and A2016396S)。; Apolipoprotein E receptor 2(ApoER2)is a receptor for the protein ApoE,the most common genetic risk factor for late-onset Alzheimer's disease(AD).It is also a key modulator of syna ptic homeostasis,in part through its ...; 关键词：HOMEOSTASIS APOE ALZHEIMER

Dysfunction of synaptic endocytic trafficking in Parkinson's disease被引量：1: 《Neural Regeneration Research》2024年第12期2649-2660,共12页Xin Yi Ng Mian Cao; Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of these...; 关键词：AUTOPHAGY auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons NEURODEGENERATION nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis: 《Neural Regeneration Research》2024年第8期1768-1771,共4页Federica Azzolini Ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari; In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying therapies.Howeve r,in recent years,several data from pre-clinical and clinical studies suggested a possible ...; 关键词：disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis NEUROPLASTICITY NEUROPROTECTION physical exercise synaptopathy

Targeting tau in Alzheimer's disease:from mechanisms to clinical therapy被引量：7: 《Neural Regeneration Research》2024年第7期1489-1498,共10页Jinwang Ye Huali Wan Sihua Chen Gong-Ping Liu; supported by the National Natural Science Foundation of China,No.82101493(to JY)。; Alzheimer’s disease is the most prevalent neurodegenerative disease affecting older adults.Primary features of Alzheimer’s disease include extra cellular aggregation of amyloid-βplaques and the accumulation of neur...; 关键词：ACETYLATION Alzheimer’s disease cognitive deficits GLIOSIS mitochondria damage NEUROINFLAMMATION phosphorylation synaptic impairments TAU tau immunotherapy

Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder被引量：4: 《Neural Regeneration Research》2024年第7期1618-1624,共7页Luyi Wang Man Xu Yan Wang Feifei Wang Jing Deng Xiaoya Wang Yu Zhao Ailing Liao Feng Yang Shali Wang Yingbo Li; supported by the Chongqing Science and Technology Committee;Natural Science Foundation of Chongqing,No.cstc2021jcyj-msxmX0065 (to YL)。; Autism spectrum disorders are a group of neurodevelopmental disorders involving more than 1100 genes,including Ctnnd2 as a candidate gene.Ctnnd2knockout mice,serving as an animal model of autis m,have been demonstrate...; 关键词：AUTISM Ctnnd2 deletion GABAergic neurons MELATONIN PI3K/Akt signal pathway prefrontal cortex social behavior spine density synaptic-associated proteins

Molecular mechanisms underlying microglial sensing and phagocytosis in synaptic pruning被引量：2: 《Neural Regeneration Research》2024年第6期1284-1290,共7页Anran Huo Jiali Wang Qi Li Mengqi Li Yuwan Qi Qiao Yin Weifeng Luo Jijun Shi Qifei Cong; supported by the National Natural Science Foundation of China;No.32200778(to QC);the Natural Science Foundation of Jiangsu Province;No.BK20220494(to QC);Suzhou Medical and Health Technology Innovation Project;No.SKY2022107(to QC);a grant from the Clinical Research Center of Neurological Disease in The Second Affiliated Hospital of Soochow University;Nos.ND2022A04(to QC)and ND2023B06(to JS)。; Microglia are the main non-neuronal cells in the central nervous system that have important roles in brain development and functional connectivity of neural circuits.In brain physiology,highly dynamic microglial proce...; 关键词：COMPLEMENT immune signals microglia molecular signal synapse elimination synapse formation synapse refinement synaptic pruning

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